IKKα Cancer Research Results

IKKα, IκB kinase alpha): Click to Expand ⟱
Source:
Type:
Expression of genes involved in nuclear factor (NF)-kappaB activation (NF-κB, IKKα) IKKα (IκB kinase alpha) is a critical component of the NF-κB signaling pathway, which plays a significant role in regulating immune responses, inflammation, and cell survival.
The NF-κB pathway, activated by IKKα, can lead to the production of pro-Inhibitors of the NF-κB pathway, including those targeting IKKα, are being investigated for their potential to treat various cancers.inflammatory cytokines that may create a tumor-promoting microenvironment.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
6536- MeSal,    Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
p‑IKKα↓, Apoptosis↑, DNAdam↑, NF-kB↓,
6491- Nimb,    Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells
- Review, PC, NA
eff↑, uPA↓, uPAR↓, p‑EGFR↓, VEGFR1↓, NF-kB↓, IKKα↓, MMP2↓, MMP9↓, TIMP2↑, TumCP↓, IGFR↓, Akt↓, ERK↓, TumCCA↓, BAX↑, BAD↑, FasL⇅, Cyt‑c↑, EPR↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   PI3K/Akt↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 1,   Cyt‑c↑, 1,   FasL⇅, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   Gli1↓, 1,   HH↓, 1,   IGFR↓, 1,   mTOR↓, 1,   PTCH1↓, 1,   Sufu↓, 1,   TumCG↓, 1,  

Migration ⓘ

MMP2↓, 2,   MMP9↓, 2,   TIMP2↑, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   uPA↓, 1,   uPAR↓, 1,   VEGFR1↓, 1,  

Angiogenesis & Vasculature ⓘ

p‑EGFR↓, 1,   EPR↑, 1,   HIF-1↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 2,   p‑IKKα↓, 1,   NF-kB↓, 3,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

p‑EGFR↓, 1,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IKKα, IκB kinase alpha)
1 Deguelin
1 Methyl salicylate / Sweet Birch oil
1 Nimbolide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:156  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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