MUC1 Cancer Research Results

MUC1, Mucin 1: Click to Expand ⟱
Source:
Type: oncoprotein
The mucin 1 (MUC1) heterodimeric oncoprotein is overexpressed in human prostate cancers with aggressive pathologic and clinical features, resulting in a poor MUC1 (Mucin 1) is a glycoprotein that is expressed on the surface of epithelial cells and plays a role in cell signaling, protection, and lubrication. It is also involved in various biological processes, including cell adhesion and immune response outcome.
MUC1 is often overexpressed in various types of cancers, including breast, ovarian, pancreatic, and colorectal cancers.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, PC, DU145 - in-vitro, PC, LNCaP
p‑ERK↑, p‑JNK↓, MUC1↓, p65↓, AR↓, TumCG↓, MEK↑, SAPK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MEK↑, 1,  

Cell Death ⓘ

p‑JNK↓, 1,  

DNA Damage & Repair ⓘ

SAPK↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   TumCG↓, 1,  

Migration ⓘ

MUC1↓, 1,  

Immune & Inflammatory Signaling ⓘ

p65↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MUC1, Mucin 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:206  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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