Treg lymp Cancer Research Results

Treg lymp, Treg lymphocytes: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Regulatory T cells (Tregs) are a subset of T lymphocytes that play a crucial role in maintaining immune tolerance and preventing autoimmune diseases. They are characterized by the expression of specific markers, such as CD4, CD25, and the transcription factor FoxP3.
Tregs are often found in high numbers within the tumor microenvironment. Their presence can suppress anti-tumor immune responses, allowing cancer cells to evade immune detection and destruction. By inhibiting the activity of effector T cells and other immune components, Tregs can promote tumor growth and metastasis.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

p‑p70S6↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

Treg lymp↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

TAMS↓, 1,  

Drug Metabolism & Resistance ⓘ

Half-Life↝, 1,  

Functional Outcomes ⓘ

OS↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Treg lymp, Treg lymphocytes
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:316  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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