TumCG Cancer Research Results

TumCG, Tumor cell growth: Click to Expand ⟱
Source:
Type:
Normal cells grow and divide in a regulated manner through the cell cycle, which consists of phases (G1, S, G2, and M).
Cancer cells often bypass these regulatory mechanisms, leading to uncontrolled proliferation. This can result from mutations in genes that control the cell cycle, such as oncogenes (which promote cell division) and tumor suppressor genes (which inhibit cell division).
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5395- Ash,    Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCP↓, HSP90↓, Akt↓, CDK4↓, TumCG↓, Apoptosis↑, AntiCan↑,
5688- BJ,    Brucea Javanica Oil Emulsion Injection inhibits proliferation of pancreatic cancer via regulating apoptosis-related genes
- vitro+vivo, PC, MIA PaCa-2
TumCG↓, TumCI↓, TumCCA↑, Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, MMP2↓, BACE↓, TOP2↓,
755- Bor,    https://aacrjournals.org/cancerres/article/67/9_Supplement/4220/535557/Boric-acid-induces-apoptosis-in-both-prostate-and
- in-vitro, Pca, DU145 - in-vitro, PC, PC3
TumCG↓, Apoptosis↑,
5836- CAP,    In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, Bxpc-3
tumCV↓, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, survivin↓, Cyt‑c↑, AIF↑, selectivity↑, JNK↑, TumCG↓,
5818- CBD,    Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress
- in-vivo, PC, PANC1
GRP78/BiP↑, ATF4↑, CHOP↑, UPR↑, TumCG↓, ER Stress↑, eff↓,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6146- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high‐fat diet
- in-vitro, PC, NA
Apoptosis↑, TumCP↓, TumCG↓, SPARC↑, Glycolysis↓, OCR↓, ATP↓, NF-kB↓, Ca+2↑,
4761- CoQ10,    Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer
- in-vitro, PC, NA - in-vivo, PC, NA
*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,
6184- Cuc,    Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
- vitro+vivo, PC, NA
TumCG↓, TumCCA↑, Apoptosis↑, JAK2↓, STAT3↓, STAT5↓, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, Bcl-xL↓, ChemoSen↑, TumVol↓, toxicity↓,
6200- Cuc,  GEM,    Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- in-vivo, PC, NA
eff↑, TumCG↓, Bcl-xL↓, Bcl-2↓, cMyc↓, Casp↑, STAT3↓, JAK2↓,
2980- CUR,    Inhibition of NF B and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation
- in-vivo, PC, NA
TumCG↓, p50↓, p65↓, NF-kB↓, Sp1/3/4↓, MMP↓, ROS↑,
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, PC, DU145 - in-vitro, PC, LNCaP
p‑ERK↑, p‑JNK↓, MUC1↓, p65↓, AR↓, TumCG↓, MEK↑, SAPK↑,
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓, TumCG↓, Apoptosis↑, TumCMig↓, TumCI↓,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2↓, Hif1a↓, VEGF↓, VEGFR2↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
688- EGCG,  GEM,    Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine
- in-vitro, PC, NA
Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,
2309- EGCG,  Chemo,    Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HPNE - in-vitro, PC, PANC1 - in-vivo, NA, NA
TumCG↓, eff↑, ROS↑, ECAR↓, ChemoSen↑, selectivity↑, Glycolysis↓, PFK↓, PKA↓, HK2∅, LDHA∅, PFKP↓, PKM2↓, H2O2↑, TumW↓,
807- GAR,    Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Apoptosis↑, TumCCA↑,
813- GAR,  GEM,    Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model
- in-vivo, PC, NA
TumCG↓, OS↑,
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,
4977- Nimb,    Nimbolide Inhibits SOD2 to Control Pancreatic Ductal Adenocarcinoma Growth and Metastasis
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, PANC1
SOD2↑, TumCG↓, TumMeta↓, ROS↑, Apoptosis↑, PI3K↓, Akt↓, EMT↓, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, Bcl-2↓,
4702- PTS,    Pterostilbene Inhibits Pancreatic Cancer In Vitro
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCG↓, BioAv↑,
3052- RES,    Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Bxpc-3
NAF1↓, ROS↑, NRF2↑, eff↑, TumCG↓,
1140- SIL,    Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth
- in-vitro, PC, AsPC-1 - in-vivo, PC, NA - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
TumCG↓, Glycolysis↓, cMyc↓, STAT3↓, TumCP↓, Weight∅, Strength↑, DNAdam↑, Casp3↑, Casp9↑, GLUT1↓, HK2↓, LDHA↓, GlucoseCon↓, lactateProd↓, PPP↓, Ki-67↓, p‑STAT3↓, cachexia↓,
5084- SSE,  GEM,    The Antitumor Activity of Sodium Selenite Alone and in Combination with Gemcitabine in Pancreatic Cancer: An In Vitro and In Vivo Study
- in-vitro, PC, PANC1 - vitro+vivo, PC, Panc02
tumCV↓, ChemoSen↑, TumCG↓, OS↑, MMP↓, AIF↑, GSH↓, Trx↓, ROS↑, AntiTum↑,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,

Showing Research Papers: 1 to 30 of 30

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 30

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

NA↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↑, 1,   GSH↓, 3,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↑, 2,   lipid-P↑, 1,   MDA↑, 1,   NAF1↓, 1,   NRF2↑, 1,   ROS↑, 11,   ROS∅, 1,   SOD2↑, 1,   Trx↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 2,   ATP↓, 4,   MEK↑, 1,   MMP↓, 6,   mtDam↑, 1,   OCR↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 2,   ECAR↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 5,   HK2↓, 2,   HK2∅, 1,   lactateProd↓, 3,   LDHA↓, 1,   LDHA∅, 1,   NADPH↓, 1,   p‑PDH↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPP↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 3,   Apoptosis↑, 10,   BAX↑, 4,   Bcl-2↓, 6,   Bcl-xL↓, 2,   Casp↑, 2,   Casp3↑, 4,   cl‑Casp3↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   HEY1↓, 1,   JNK↑, 1,   p‑JNK↓, 1,   survivin↓, 2,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

p‑p70S6↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   cl‑PARP↑, 2,   SAPK↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1/2/5/9↓, 1,   CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   p‑ERK↑, 1,   FOSL1↑, 1,   Gli1↓, 2,   HH↓, 2,   IGF-1↓, 2,   p‑IGFR↓, 1,   mTOR↓, 2,   NOTCH1↓, 1,   NOTCH3↓, 1,   PI3K↓, 2,   PTCH1↓, 1,   Shh↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT5↓, 1,   Sufu↓, 1,   TOP2↓, 1,   TumCG↓, 30,   Wnt↓, 1,  

Migration ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   GLI2↓, 1,   Ki-67↓, 1,   MMP2↓, 3,   MMP9↓, 3,   MUC1↓, 1,   PKA↓, 1,   Snail↓, 1,   SPARC↑, 1,   Treg lymp↓, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 6,   TumMeta↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,   HIF-1↓, 1,   Hif1a↓, 1,   TAMS↓, 1,   VEGF↓, 2,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IKKα↓, 1,   IL6↓, 1,   IL8↓, 1,   JAK2↓, 2,   NF-kB↓, 4,   p50↓, 1,   p65↓, 2,  

Protein Aggregation ⓘ

BACE↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 4,   Dose↝, 3,   Dose∅, 1,   eff↓, 4,   eff↑, 7,   Half-Life↝, 1,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ferritin↓, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cachexia↓, 1,   OS↑, 3,   Strength↑, 1,   toxicity↓, 4,   toxicity↑, 2,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 160

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Mitochondria & Bioenergetics ⓘ

ETC↝, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,  

Functional Outcomes ⓘ

chemoPv↑, 1,   toxicity↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: TumCG, Tumor cell growth
4 Gemcitabine (Gemzar)
3 3-bromopyruvate
2 Cucurbitacin
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Garcinol
1 Ashwagandha(Withaferin A)
1 Brucea javanica
1 Boron
1 Capsaicin
1 Cannabidiol
1 Chocolate
1 Citric Acid
1 Coenzyme Q10
1 Bicalutamide
1 Deguelin
1 diet FMD Fasting Mimicking Diet
1 Vitamin C (Ascorbic Acid)
1 Ellagic acid
1 Chemotherapy
1 Juglone
1 Nimbolide
1 Pterostilbene
1 Resveratrol
1 Silymarin (Milk Thistle) silibinin
1 Selenite (Sodium)
1 Urolithin
1 Vitamin B1/Thiamine
1 Dichloroacetate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:323  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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