Zeb1 Cancer Research Results

Zeb1, Zinc finger E-box-binding homeobox 1: Click to Expand ⟱
Source:
Type: protein
Transcription factor that promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma cells.
Zinc finger E-box-binding homeobox 1 (ZEB1) is a transcription factor that plays a significant role in various biological processes, including embryonic development, cell differentiation, and epithelial-to-mesenchymal transition (EMT).

By repressing epithelial markers (e.g., E-cadherin) and promoting mesenchymal genes, Zeb1 facilitates cell migration, invasion, and metastasis.

Cancers (such as breast, colorectal, pancreatic, and lung cancers), Zeb1 is frequently upregulated. Zeb1 may be more prominent in specific tumor regions (e.g., invasive fronts) where EMT is actively occurring.
High levels of Zeb1 have been correlated with poor patient outcomes in multiple cancers.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
688- EGCG,  GEM,    Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy When Combined with Gemcitabine
- in-vitro, PC, NA
Zeb1↓, β-catenin/ZEB1↓, Vim↓, Akt↓, p‑IGFR↓, TumCG↓, TumCMig↓, TumCI↓,
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓, Nanog↓, TumCG↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Bcl-2↓, 2,   Casp3↑, 1,   Casp7↑, 1,   survivin↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 2,   Gli↓, 1,   Gli1↓, 2,   HH↓, 2,   p‑IGFR↓, 1,   Nanog↓, 2,   OCT4↓, 2,   PDGFRA↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 2,   Smo↓, 2,   TumCG↓, 1,   TumCG↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   GLI2↓, 2,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   Vim↓, 1,   Zeb1↓, 3,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Zeb1, Zinc finger E-box-binding homeobox 1
2 EGCG (Epigallocatechin Gallate)
1 Gemcitabine (Gemzar)
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:341  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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