IL8 Cancer Research Results

IL8, Interleukin-8: Click to Expand ⟱
Source:
Type:
Interleukin-8 (IL-8), also known as CXCL8, is a chemokine primarily involved in the recruitment and activation of neutrophils. Its role in cancer is significant, as it can influence tumor growth, metastasis, and the tumor microenvironment.
IL-8 is a chemokine frequently produced in the tumor microenvironment by human malignant cells. IL-8 plays key roles in the immunobiology of human malignancies and resistance to treatments. Circulating IL-8 concentration reflects tumor burden.

In many cancers have elevated levels of IL-8 and are associated with increased tumor aggressiveness, metastasis, and poorer overall survival. Elevated IL-8 often correlates with a more inflammatory tumor microenvironment, which can facilitate tumor progression.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2↓, Hif1a↓, VEGF↓, VEGFR2↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

NA↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   HEY1↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1/2/5/9↓, 1,   CDK2↓, 1,   cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   Shh↓, 1,   TumCG↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   GLI2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Snail↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VEGF↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL6↓, 1,   IL8↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IL8, Interleukin-8
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:368  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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