Gli Cancer Research Results

Gli, GLI: Click to Expand ⟱
Source:
Type: protein/gene
The GLI gene family consists of three members: GLI1, GLI2, and GLI3. These genes encode transcription factors that play crucial roles in the Hedgehog signaling pathway, which is important for various developmental processes and cellular functions.
: In many cancers, aberrant activation of the Hedgehog signaling pathway leads to increased GLI expression. This can occur through mutations in Hedgehog pathway components or through the overexpression of Hedgehog ligands.

-GLI factors are implicated in maintaining cancer stem cell populations. These cells often drive tumor recurrence, metastasis, and resistance to therapy because they have self-renewal capabilities. The overactivation of GLI may, therefore, help sustain these subpopulations within tumors.

Elevated GLI expression levels can serve as a prognostic marker in certain cancers, indicating a more aggressive disease and poorer outcomes.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 2,   Casp7↑, 2,   survivin↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 2,   EMT↓, 1,   Gli↓, 2,   Gli1↓, 2,   HH↓, 1,   Nanog↓, 2,   OCT4↓, 2,   PDGFRA↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 2,   Smo↓, 2,  

Migration ⓘ

GLI2↓, 2,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Zeb1↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Gli, GLI
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:434  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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