TumVol Cancer Research Results

TumVol, Tumor Volume: Click to Expand ⟱
Source:
Type:
Tumor Volume
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
940- BBR,    Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
- vitro+vivo, PC, PANC1 - in-vivo, PC, MIA PaCa-2
LDHA↓, lactateProd↓, AMPKα↓, TumVol↓, Ki-67↓,
6555- BSB,    Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer
- vitro+vivo, PC, NA
TumCP↓, TumCI↓, p‑FAK↓, TumVol↓, Ki-67↓,
6643- Cen,    Asiaticoside inhibits epithelial-mesenchymal transition and stem cell-like properties of pancreatic cancer PANC-1 cells by blocking the activation of p65 and p38MAPK
- vitro+vivo, PC, PANC1
tumCV↓, Ki-67↓, PCNA↓, N-cadherin↓, Vim↓, SOX2↓, OCT4↓, p65↓, MAPK↓, CD44↓, CD133↓, E-cadherin↑, TumVol↓, TumCP↓, EMT↓, CSCsMark↓,
6184- Cuc,    Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells
- vitro+vivo, PC, NA
TumCG↓, TumCCA↑, Apoptosis↑, JAK2↓, STAT3↓, STAT5↓, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, Bcl-xL↓, ChemoSen↑, TumVol↓, toxicity↓,
5049- HPT,    Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
- vitro+vivo, PC, Panc02 - vitro+vivo, PC, Bxpc-3
tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
215- MFrot,  MF,    Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields
- in-vitro, PC, CAF
TumVol↓, lysoMP↑, CAFs/TAFs↓, eff↑,
1251- RT,  OLST,    Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions
- in-vitro, BC, MCF-7 - in-vitro, PC, PANC1 - in-vivo, NA, NA
TumVol↓, *CEA↓, *FASN↓, *ROS↓, *MDA↓, *GSH↑, Apoptosis↑,
6433- T4O,  CET,    Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers
- in-vitro, Colon, HT29 - in-vitro, CRC, HCT116 - in-vitro, PC, COLO357 - Human, Colon, NA
TumCG↓, eff↑, ChemoSen↑, Apoptosis↑, TumVol↓, TumW↓, *Inflam↓, *antiOx↓, BioAv↝,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,
2105- TQ,    Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation
- in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Hs766t - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, P53↑, Bcl-2↓, P21↑, ac‑H4↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, TumVol↓,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 4,   Bcl-2↓, 2,   Bcl-xL↓, 2,   proCasp↑, 1,   lysoMP↑, 1,   MAPK↓, 1,   survivin↓, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H4↑, 1,   other↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↓, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   CSCsMark↓, 1,   EMT↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   OCT4↓, 1,   SOX2↓, 1,   STAT3↓, 1,   STAT5↓, 1,   TOP2↓, 1,   TumCG↓, 2,  

Migration ⓘ

CAFs/TAFs↓, 1,   E-cadherin↑, 1,   p‑FAK↓, 1,   Ki-67↓, 4,   MUC4↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 4,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   JAK2↓, 1,   NF-kB↓, 1,   p65↓, 1,   PGE1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 2,   eff↑, 3,  

Clinical Biomarkers ⓘ

Ki-67↓, 4,  

Functional Outcomes ⓘ

toxicity↓, 1,   TumVol↓, 11,   TumW↓, 1,  
Total Targets: 63

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   GSH↑, 1,   MDA↓, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

FASN↓, 1,  

Migration ⓘ

CEA↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Clinical Biomarkers ⓘ

CEA↓, 1,  
Total Targets: 8

Scientific Paper Hit Count for: TumVol, Tumor Volume
2 Magnetic Fields
2 Thymoquinone
1 Berberine
1 α-Bisabolol / Chamomile oil
1 Centella asiatica / Gotu kola → asiaticoside
1 Cucurbitacin
1 Hyperthermia
1 Magnetic Field Rotating
1 Rutin
1 Orlistat
1 Terpinen-4-ol / Tea Tree Oil
1 cetuximab
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:530  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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