GLUT4 Cancer Research Results

GLUT4, Glucose Transporter 4: Click to Expand ⟱
Source:
Type:
GLUT4 (Glucose Transporter 4) is a protein that plays a crucial role in glucose metabolism by facilitating the transport of glucose across cell membranes. GLUT4 is a member of the facilitated glucose transporter family and is primarily expressed in adipose tissue and skeletal muscle.
GLUT4 has been shown to be overexpressed in many types of tumors, and its expression has been linked to cancer cell growth, survival, and metastasis.
GLUT4 is involved in the regulation of glucose metabolism in cancer cells, and its overexpression has been shown to promote glucose uptake and energy production in cancer cells.
GLUT4 promotes glucose uptake and energy production in cancer cells.
GLUT4 expression is linked to poor prognosis in various types of cancer.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   HK2↓, 1,   LDHA↓, 1,  

Cell Death ⓘ

Casp∅, 1,   necrosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Migration ⓘ

p‑FAK↓, 1,   MMP9↓, 1,   MUC4↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GLUT4, Glucose Transporter 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:774  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page