GAPDH Cancer Research Results

GAPDH, Glyceraldehyde-3-phosphate dehydrogenase: Click to Expand ⟱
Source:
Type: gene
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a housekeeping gene that encodes a protein involved in glycolysis, a metabolic pathway that converts glucose into energy. GAPDH is a crucial enzyme in the glycolytic pathway, and its expression is often used as a control gene in molecular biology experiments.
GAPDH has been shown to be overexpressed in various types of tumors, including breast, lung, colon, and prostate cancer.
Cancer cells often exhibit increased glycolysis, even in the presence of oxygen, a phenomenon known as the Warburg effect. GAPDH overexpression can contribute to this increased glycolysis.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

GAPDH↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

MMP9↓, 1,   TumCI↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 2,   toxicity↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GAPDH, Glyceraldehyde-3-phosphate dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:812  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page