CDK4 Cancer Research Results
CDK4, Cyclin-dependent kinase 4: Click to Expand ⟱
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Cyclin-dependent kinase 4 (CDK4) is a key regulator of the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression and activity are often altered in various cancers, contributing to tumorigenesis.
CDK4 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker.
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PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
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Scientific Papers found: Click to Expand⟱
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vitro+vivo, |
PC, |
PANC1 |
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in-vitro, |
PC, |
MIA PaCa-2 |
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TumCP↓, HSP90↓, Akt↓, CDK4↓, TumCG↓, Apoptosis↑, AntiCan↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Akt↓, 1, Apoptosis↑, 1,
Protein Folding & ER Stress ⓘ
HSP90↓, 1,
Cell Cycle & Senescence ⓘ
CDK4↓, 1,
Proliferation, Differentiation & Cell State ⓘ
TumCG↓, 1,
Migration ⓘ
TumCP↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 1,
Total Targets: 7
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: CDK4, Cyclin-dependent kinase 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:21 Cells:% prod#:% Target#:894 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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