ABCG2 Cancer Research Results

ABCG2, BCRP/ATP-binding cassette sub-family G member 2: Click to Expand ⟱
Source:
Type:
ATP-binding cassette sub-family G member 2 (ABCG2) is a protein that plays a crucial role in the transport of various substances across cell membranes, including drugs, lipids, and xenobiotics. ABCG2 is often high and associated with poor prognosis.

BCRP (ABCG2; breast cancer resistance protein) is an ATP-binding cassette efflux transporter that can export multiple anticancer drugs from cancer cells. In tumors, increased BCRP activity may lower intracellular drug accumulation and contribute to multidrug resistance, reduced chemotherapy response, and survival of resistant cancer stem-like or side-population cells. Therefore, for anti-cancer interpretation, BCRP/ABCG2 downregulation or inhibition is generally favorable when the therapeutic goal is to increase intracellular exposure to BCRP-substrate drugs. However, BCRP also protects normal tissues such as intestinal epithelium, liver, kidney, placenta, and blood-brain barrier, so systemic inhibition may alter drug distribution and toxicity.



PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
816- GAR,    Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
- in-vitro, PC, PANC1
Mcl-1↓, EZH2↓, ABCG2↓, Gli1↓, NOTCH1↓, miR-200c↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Mcl-1↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   NOTCH1↓, 1,  

Migration ⓘ

miR-200c↑, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABCG2, BCRP/ATP-binding cassette sub-family G member 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:900  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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