HDAC1 Cancer Research Results

HDAC1, Histone Deacetylase 1: Click to Expand ⟱
Source:
Type:
HDAC1 is an enzyme that removes acetyl groups from histone tails, resulting in chromatin condensation and transcriptional repression.
– By modulating the acetylation status of histones, HDAC1 plays a key role in regulating gene expression involved in cell cycle progression, differentiation, apoptosis, and DNA repair.
– Aberrant expression or activity of HDAC1 has been linked to several cancers.
– Overexpression of HDAC1 can lead to the repression of tumor suppressor genes, thereby promoting oncogenic programs and contributing to tumor progression.
– HDAC1 is often associated with a more aggressive tumor phenotype and, in some contexts, a poorer clinical prognosis.
Therapeutic Targeting:
– HDAC inhibitors (HDACis) have emerged as anticancer agents; they work by inhibiting HDAC activity to restore acetylation levels on histones and nonhistone proteins.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
2105- TQ,    Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation
- in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Hs766t - in-vivo, NA, NA
tumCV↓, TumCP↓, TumCCA↑, Apoptosis↑, P53↑, Bcl-2↓, P21↑, ac‑H4↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, TumVol↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,  

Transcription & Epigenetics ⓘ

ac‑H4↑, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC1, Histone Deacetylase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:982  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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