LC3B Cancer Research Results

LC3B, microtubule-associated protein 1 light chain 3 beta: Click to Expand ⟱
Source:
Type:
LC3B (microtubule-associated protein 1 light chain 3 beta) is a key protein involved in the autophagy pathway and is widely used as a marker to assess autophagic activity in cells. While not a classical immunogenic cell death (ICD) marker, its expression in tumors has been linked with several prognostic implications, often reflecting the balance between autophagy’s tumor-suppressive and tumor-promoting roles.

• LC3B plays a central role in autophagosome formation.
• Its conversion from LC3BI (cytosolic form) to LC3BII (lipidated, membrane-bound form) is a key indicator of autophagy activation.
• LC3B is sometimes evaluated together with other autophagy-related proteins (such as Beclin-1) to generate an overall picture of autophagic activity in the tumor.

– In several cancers (e.g., pancreatic, colorectal, and breast cancers), elevated LC3B levels have been associated with enhanced autophagy, which can promote tumor cell survival under stress conditions (such as hypoxia or chemotherapy).
– Certain studies, particularly in early-stage tumors or specific subtypes, have found that higher LC3B correlates with improved outcomes.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

LC3B↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   p‑P53↑, 1,   p‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↑, 1,  

Migration ⓘ

RIP3↑, 1,   p‑RIP3↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↓, 1,   eff↑, 1,   selectivity↓, 1,   selectivity↑, 2,  

Functional Outcomes ⓘ

TumW↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LC3B, microtubule-associated protein 1 light chain 3 beta
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:1081  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page