FOSL1 Cancer Research Results

FOSL1, FOSL1 (FRA-1): Click to Expand ⟱

Source:

Type:

FOSL1 (FRA-1)
FOSL1 is a member of the activator protein-1 (AP-1) transcription factor complex. It is involved in regulating genes that control proliferation, differentiation, survival, and metastasis.

– Observations: Overexpression of FOSL1 has been associated with aggressive subtypes, epithelial–mesenchymal transition (EMT), and increased invasiveness.

– Prognostic Implication: Higher FOSL1 levels often correlate with poorer overall survival and disease progression.

PC, Pancreatic Cancer: Click to Expand ⟱

Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑

Scientific Papers found: Click to Expand⟱

1921-

JG,

Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis

in-vitro,

PC,

vitro+vivo,

PC,

TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1, GSH↓, 1, HO-1↑, 1, Iron↑, 1, lipid-P↑, 1, MDA↑, 1, ROS↑, 1,

Cell Death ⓘ

Ferroptosis↑, 1,

Proliferation, Differentiation & Cell State ⓘ

FOSL1↑, 1, TumCG↓, 1,
Total Targets: 10

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FOSL1, FOSL1 (FRA-1)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells