TSP-1 Cancer Research Results

TSP-1, Thrombospondin-1: Click to Expand ⟱
Source:
Type:
(TSP-1) is the first reported endogenous anti-angiogenic factor that can inhibit angiogenesis and tumorigenesis.
Thrombospondin-1 (TSP-1) is a glycoprotein that plays a significant role in various biological processes, including cell adhesion, migration, and angiogenesis. It is part of the thrombospondin family of proteins and is known for its ability to regulate the formation of new blood vessels (angiogenesis) and modulate the immune response.
TSP-1 is often considered a tumor suppressor because it can inhibit angiogenesis by binding to and activating certain receptors on endothelial cells, leading to reduced blood vessel formation. This can limit the supply of nutrients and oxygen to tumors, potentially inhibiting their growth.
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
57- QC,    Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo
- vitro+vivo, PC, PC3
TSP-1↑, angioG↓, TumCMig↓, TumCI↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

TSP-1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TSP-1, Thrombospondin-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:320  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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