ARE/EpRE Cancer Research Results
ARE/EpRE, electrophile response element/antioxidant response element: Click to Expand ⟱
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The electrophile response element (EpRE), also called the antioxidant response element (ARE), is involved in the up-regulation of many antioxidant/detoxifying genes.
Electrophile response element (EpRE) is essential for regulation of many genes involved in protection against toxic agents.
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PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
Pca, |
LNCaP |
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in-vitro, |
Pca, |
PC3 |
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in-vitro, |
PC, |
DU145 |
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AR↓, ARE/EpRE↑, TumCP↓, PSA↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
ARE/EpRE↑, 1,
Migration ⓘ
TumCP↓, 1,
Immune & Inflammatory Signaling ⓘ
PSA↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Clinical Biomarkers ⓘ
AR↓, 1, PSA↓, 1,
Total Targets: 6
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: ARE/EpRE, electrophile response element/antioxidant response element
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:21 Cells:% prod#:% Target#:504 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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