miR-200c Cancer Research Results

miR-200c, miR-200c: Click to Expand ⟱
Source:
Type: tumour-suppressor miRNA
miR-200c studied particularly in the regulation of epithelial-to-mesenchymal transition (EMT) and cancer metastasis.
miR-200c is a member of the miR-200 family, which includes miR-200a, miR-200b, and miR-200c. These miRNAs are known to play a crucial role in maintaining epithelial cell identity and suppressing EMT, a process by which epithelial cells acquire a mesenchymal phenotype and become more migratory and invasive.

miR-200c has been shown to target several genes involved in EMT and cancer progression, including:

     ZEB1 and ZEB2, transcription factors that promote EMT and cancer metastasis.
     TGF-β, a cytokine that promotes EMT and cancer progression.
     Vimentin, a protein that is highly expressed in mesenchymal cells and is associated with cancer metastasis.

The overexpression of miR-200c has been shown to inhibit EMT and cancer metastasis in various types of cancer, including breast, lung, and ovarian cancer. Conversely, the downregulation of miR-200c has been associated with cancer progression and poor prognosis.

Downregulated in: lung, CRC, GC, pancreatic, HCC (associated with poor prognosis).
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
816- GAR,    Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells
- in-vitro, PC, PANC1
Mcl-1↓, EZH2↓, ABCG2↓, Gli1↓, NOTCH1↓, miR-200c↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Mcl-1↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   NOTCH1↓, 1,  

Migration ⓘ

miR-200c↑, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-200c, miR-200c
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:765  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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