eff Cancer Research Results

eff, efficacy: Click to Expand ⟱
Source:
Type:
Power to enhance an anti cancer effect
PC, Pancreatic Cancer: Click to Expand ⟱
Pancreatic Cancer: Hypoxia (low oxygen tension) is commonly found in solid tumors. Hypoxia-inducible factor-1 (HIF-1),is a key mediator of the cellular response to hypoxia and is overexpressed in a wide variety of solid tumors, including pancreatic cancer.
Nanog is highly expressed in CSCs compared to normal cells [93–97]
HIF-1↑
Scientific Papers found: Click to Expand⟱
5274- 3BP,    ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
- in-vitro, PC, NA
eff↑, TumCG↓, TumMeta↓, toxicity↝, Glycolysis↓, toxicity↓, Dose↝,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
2597- Ba,    Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
- Review, PC, NA
chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,
5637- BCA,  ATV,    Combination Treatment of Biochanin A and Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism and Inducing Cell Cycle Arrest in Pancreatic Cancer Cells
- in-vitro, PC, AsPC-1 - in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
eff↑, TumCI↓, STAT3↓, Apoptosis↑,
5510- bemA,    Combined inhibition of ACLY and CDK4/6 reduces cancer cell growth and invasion
- in-vitro, BC, MDA-MB-231 - in-vitro, PC, NA
eff↑, Apoptosis↑, TumCI↓, ACLY↓, LDL↓, eff↑, TumCP↓,
5722- BF,    Bufalin exerts antitumor effects by inducing cell cycle arrest and triggering apoptosis in pancreatic cancer cells
- in-vitro, PC, PANC1
Apoptosis↑, TumCCA↑, HSP27↓, p‑Akt↓, proCasp3↑, proCasp9↑, Bcl-2↝, BAX↝, eff↑,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
6073- CHL,  GEM,    Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis
- in-vitro, PC, NA
ChemoSen↑, eff↑, AntiTum↑, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, GSH↓, ROS↑, HSP70/HSPA5↑,
1584- Citrate,    Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, i-Ca+2↓, TumCMig↓, CD133↓, pH↑, eff↑, Ki-67↓, eff↑,
6200- Cuc,  GEM,    Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer
- in-vivo, PC, NA
eff↑, TumCG↓, Bcl-xL↓, Bcl-2↓, cMyc↓, Casp↑, STAT3↓, JAK2↓,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
2309- EGCG,  Chemo,    Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HPNE - in-vitro, PC, PANC1 - in-vivo, NA, NA
TumCG↓, eff↑, ROS↑, ECAR↓, ChemoSen↑, selectivity↑, Glycolysis↓, PFK↓, PKA↓, HK2∅, LDHA∅, PFKP↓, PKM2↓, H2O2↑, TumW↓,
1962- GamB,  HCQ,    Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species
- in-vitro, PC, NA
LC3II↑, Beclin-1↑, p62↓, MMP↓, ROS↑, TumAuto↑, eff↑,
215- MFrot,  MF,    Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields
- in-vitro, PC, CAF
TumVol↓, lysoMP↑, CAFs/TAFs↓, eff↑,
595- MFrot,  VitC,  MF,    The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, SW-620 - in-vitro, NA, HT1080 - in-vitro, Pca, PC3 - in-vitro, OS, U2OS - in-vitro, BC, MCF-7 - in-vitro, Nor, CCD-18Co
TumCD↑, eff↑, *TumCG∅,
5606- NaHCO3,    Effects of Alkalization Therapy on Chemotherapy Outcomes in Metastatic or Recurrent Pancreatic Cancer
- Trial, PC, NA
Dose↝, OS↑, eff↑,
5603- NaHCO3,  immuno,    Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
- in-vitro, BC, MCF-7 - in-vitro, PC, MIA PaCa-2 - in-vitro, GBM, U87MG
eff↑, e-pH↑, PD-L1↓,
2061- PB,  Chemo,    Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells
- in-vitro, PC, PANC1 - in-vitro, PC, COLO357 - in-vitro, PC, Bxpc-3
HDAC↓, Apoptosis↑, eff↑, selectivity↑, TumCCA↑, eff↑, selectivity↑,
1674- PBG,  SDT,  HPT,    Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells
- in-vitro, PC, PANC1 - in-vitro, Nor, H6c7
tumCV↓, ROS↑, eff↑, Dose∅, selectivity↑, MMP↓, mtDam↑, cl‑PARP↑, p‑ERK↓, p‑JNK↑, p‑p38↑, eff↓, ChemoSen↑,
2956- PL,    Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- in-vitro, PC, NA
ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,
3052- RES,    Resveratrol-Induced Downregulation of NAF-1 Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine via the ROS/Nrf2 Signaling Pathways
- in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2 - in-vitro, PC, Bxpc-3
NAF1↓, ROS↑, NRF2↑, eff↑, TumCG↓,
2353- TQ,    The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
- Review, PC, NA
BioAv↝, BioAv↑, MUC4↓, PKM2↓, eff↑, TumVol↓, HDAC↓, NF-kB↓, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, COX2↓, PGE1↓,
1888- VitB1/Thiamine,  DCA,    High Dose Vitamin B1 Reduces Proliferation in Cancer Cell Lines Analogous to Dichloroacetate
- in-vitro, PC, SK-N-BE - NA, PC, PANC1
p‑PDH↓, GlucoseCon↓, lactateProd↓, MMP↓, Casp3↑, eff↑, PDKs↓, selectivity↑, TumCG↓, Dose∅, MMP↓, ROS∅, toxicity↑, antiOx↑,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,

Showing Research Papers: 1 to 26 of 26

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 26

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   compI↓, 1,   Ferroptosis↓, 1,   GPx↓, 2,   GSH↓, 3,   GSH/GSSG↓, 1,   H2O2↑, 1,   HO-1↓, 1,   Iron↑, 1,   NAF1↓, 1,   NRF2↑, 1,   Prx6↑, 1,   ROS↑, 9,   ROS∅, 1,   SOD↓, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   compIII↓, 1,   MMP↓, 6,   mtDam↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

12LOX?, 1,   ACLY↓, 2,   citrate↓, 1,   cMyc↓, 2,   ECAR↓, 2,   FASN↓, 1,   GAPDH↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   HK2∅, 1,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 1,   LDHA∅, 1,   LDL↓, 1,   PDH↑, 1,   p‑PDH↓, 1,   PDK1↓, 1,   PDKs↓, 1,   PFK↓, 1,   PFKP↓, 1,   PKM2↓, 2,   Warburg↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 7,   BAX↑, 2,   BAX↝, 1,   Bcl-2↓, 5,   Bcl-2↝, 1,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 4,   cl‑Casp3∅, 1,   proCasp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   proCasp9↑, 1,   Cyt‑c↑, 2,   Ferroptosis↓, 1,   p‑JNK↑, 1,   lysoMP↑, 1,   Mcl-1↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Necroptosis↑, 1,   p‑p38↑, 1,   survivin↓, 2,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   p‑P53↑, 1,   p‑PARP↑, 1,   cl‑PARP↑, 1,   cl‑PARP∅, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   Gli↓, 1,   Gli1↓, 1,   HDAC↓, 2,   HH↓, 1,   IGF-1↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PTCH1↓, 1,   PTCH2↓, 1,   Shh↓, 1,   Smo↓, 1,   STAT3↓, 2,   TumCG↓, 7,   TumCG↑, 1,  

Migration ⓘ

i-Ca+2↓, 1,   CAFs/TAFs↓, 1,   GLI2↓, 1,   Ki-67↓, 1,   MMP9↓, 1,   MUC4↓, 1,   PKA↓, 1,   RIP3↑, 1,   p‑RIP3↑, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 5,   TumCMig↓, 3,   TumCP↓, 2,   TumMeta↓, 1,   Zeb1↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   JAK2↓, 1,   NF-kB↓, 1,   PD-L1↓, 1,   PGE1↓, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,   e-pH↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 2,   ChemoSen↑, 5,   Dose↝, 5,   Dose∅, 3,   eff↓, 4,   eff↑, 30,   selectivity↓, 1,   selectivity↑, 9,  

Clinical Biomarkers ⓘ

Ferritin↓, 1,   Ki-67↓, 1,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   chemoP↑, 1,   OS↑, 1,   toxicity↓, 3,   toxicity↑, 2,   toxicity↝, 1,   TumVol↓, 2,   TumW↓, 2,  
Total Targets: 153

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

ROS∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG∅, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 3

Scientific Paper Hit Count for: eff, efficacy
3 Vitamin C (Ascorbic Acid)
2 3-bromopyruvate
2 Gemcitabine (Gemzar)
2 EGCG (Epigallocatechin Gallate)
2 Chemotherapy
2 Magnetic Field Rotating
2 Magnetic Fields
2 Bicarbonate(Sodium)
1 Apigenin (mainly Parsley)
1 Metformin
1 Baicalein
1 Biochanin A
1 Atorvastatin
1 bempedoic acid
1 Bufalin/Huachansu
1 Capsaicin
1 Chlorophyllin
1 Citric Acid
1 Cucurbitacin
1 diet FMD Fasting Mimicking Diet
1 Gambogic Acid
1 hydroxychloroquine
1 immunotherapy
1 Phenylbutyrate
1 Propolis -bee glue
1 SonoDynamic Therapy UltraSound
1 Hyperthermia
1 Piperlongumine
1 Resveratrol
1 Thymoquinone
1 Vitamin B1/Thiamine
1 Dichloroacetate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:21  Cells:%  prod#:%  Target#:961  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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