ABL1 Cancer Research Results

ABL1, Tyrosine-protein kinase ABL1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
ABL1 is a protein tyrosine kinase involved in cell differentiation, division and stress response.
ABL1 (Abelson murine leukemia viral oncogene homolog 1) is a gene that encodes a protein tyrosine kinase, which plays a crucial role in various cellular processes, including cell division, differentiation, and response to stress.
ABL1, its role as an oncogene is most prominently illustrated by the BCR-ABL fusion protein, which is formed through a chromosomal translocation between the ABL1 gene and the BCR gene.
High ABL1 Expression: In some cancers, high levels of ABL1 expression may correlate with poor prognosis, while in others, it may not have a significant impact.
Pca, Prostate Cancer: Click to Expand ⟱
Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.
Scientific Papers found: Click to Expand⟱
6590- DAS,    Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
- in-vitro, Pca, NA
Src↓, ABL1↓, BioAv↑, TumCG↓, Dose↓, TumCA↓, TumCMig↓, TumCI↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ABL1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Src↓, 1,   TumCG↓, 1,  

Migration ⓘ

TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABL1, Tyrosine-protein kinase ABL1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:22  Cells:%  prod#:%  Target#:1  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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