Copper Cancer Research Results

Copper, Copper: Click to Expand ⟱

Source:

Type:

Copper is an essential trace element that plays a critical role in various biological processes, including iron metabolism, energy production, and the functioning of the immune system. However, its relationship with cancer is complex, as both copper deficiency and excess can influence cancer development and progression.
Many cancer cells exhibit elevated levels of copper compared to normal cells. This accumulation can support tumor growth and metastasis by:
Enhancing angiogenesis (the formation of new blood vessels).
Promoting cell proliferation and survival.
Supporting the activity of copper-dependent enzymes that facilitate tumor progression. Copper and Oxidative Stress: While copper is essential for antioxidant enzymes, excess copper can lead to the generation of reactive oxygen species (ROS), contributing to oxidative stress.
Elevated copper levels can promote inflammation and support the growth of tumors.
Copper Chelation Therapy: Given the role of copper in cancer progression, copper chelation (the use of agents that bind copper and promote its excretion) has been explored as a potential therapeutic strategy.

Pca, Prostate Cancer: Click to Expand ⟱

Prostate Cancer: Alterations in genes such as ERG, SPOP, MYC, androgen receptor (AR), and CHD1, drive PCa progression.
TP53 is the most commonly mutated gene in human cancer.
HH↑, GLI-1↑, SHH↑ P53↓
The loss of p53 and/or other tumor suppressor genes, reduced capacity for DNA repair, the dysfunction of telomerase activity, and changes in the pathways that govern the growth of cells also mediate the progression of Pca.
It has been well documented that Ca2+ influx and MDR1 upregulation are highly associated with GEM metabolism in human pancreatic carcinoma.
Increased Growth factor IGF-1/IGF-1R axis activation mediated by both PI3K/Akt or RAF/MEK/ERK system and AR expression remains important in the development and progression of prostate cancer.
It has been demonstrated that prostate cancer cells are relatively sensitive to heat stress.
Long non-coding RNA MALAT1 has been reported as an oncogenic target in multiple types of cancers, including PC.

Scientific Papers found: Click to Expand⟱

6172-

TM,

Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer

Trial,

Pca,

Copper↓, angioG∅, eff∅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Copper↓, 1,

Angiogenesis & Vasculature ⓘ

angioG∅, 1,

Drug Metabolism & Resistance ⓘ

eff∅, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Copper, Copper

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells