Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

RCC, Renal cell Carcinoma: Click to Expand ⟱

Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, accounting for 80–90% of kidney neoplasms.
The activation of the mTOR pathway has been found in RCC and is correlated with high grade and poor prognostic patient features (41,42).

Scientific Papers found: Click to Expand⟱

7261-

Gink,

Ginkgetin induces apoptosis in 786-O cell line via suppression of JAK2-STAT3 pathway

in-vitro,

RCC,

786-O

TumCG↓, Casp3↑, Casp8↑, Casp9↑, JAK2↓, STAT3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Casp3↑, 1, Casp8↑, 1, Casp9↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1, TumCG↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK2↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells