other Cancer Research Results

other, other: Click to Expand ⟱
Source:
Type:
custom
Var, Various Cancer: Click to Expand ⟱
Cyclooxygenase (COX)-2 overexpression has been noted in various cancers. PI3Ks/AKT pathways are over-activated in several types of cancers.
EGFR altered activity has been noted in various pathological conditions. However, its regulation is an important step in the inhibition of cancer. In this regard, EGCG shows a pivotal role in the inhibition of EGFR activity.
Activating protein-1 transcription factor has been associated with pathogenesis including cancer.
Activation of the sonic hedgehog (Shh) pathway is required for the growth of numerous tissues and organs and recent evidence indicates that this pathway is often recruited to stimulate growth of cancer stem cells (CSCs) and to orchestrate the reprogramming of cancer cells via epithelial mesenchymal transition (EMT). Increased expression of Nanog has been associated with the aggressive nature of certain cancers, highlighting its role in promoting cancer stem cell characteristics.
The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors.
The process of cell apoptosis is often accompanied by the destruction of mitochondrial transmembrane potential, which is widely regarded as one of the earliest events in the process of cell apoptosis.
Human malignancies frequently exhibit mutations in the TGF-β pathway, and overactivation of this system is linked to tumor growth by promoting angiogenesis and inhibiting the innate and adaptive antitumor immune responses50.
Several studies have demonstrated that high cyclin D1 expression was observed in cancers including breast, lung, prostate, lymph node and colorectal cancers [23–25].
The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell.
Vimentin is overexpressed in various epithelial cancers, including prostate cancer, gastrointestinal tumors, tumors of the central nervous system, breast cancer, malignant melanoma, and lung cancer. Vimentin’s overexpression in cancer correlates well with accelerated tumor growth, invasion, and poor prognosis; however, the role of vimentin in cancer progression remains obscure.
Heat shock proteins (HSPs) are normally induced under environmental stress to serve as chaperones for maintenance of correct protein folding but they are often overexpressed in many cancers, including breast cancer.
Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
Since increased Nrf2 gene expression is one of the main mechanisms of cancer cells in resisting chemotherapeutic drugs and survival in oxidative conditions; finding compounds with the ability to suppress Nrf2 gene expression with minimum side effects can be considered an important strategy for increasing the sensitivity of cancer cells to chemotherapy.
Overexpression of c-met stimulates proliferation, migration and invasion in various types of cancer including prostate cancer.
Overexpression of TGFα and EGFR by many carcinomas correlates with the development of cancer metastasis, resistance to chemotherapy and poor prognosis.
-More than 50% of human cancers have a mutated nonfunctional p53.
-CBS, and/or CSE and/or 3-MST is overexpressed in many forms of cancer
Scientific Papers found: Click to Expand⟱
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
5270- 5-ALA,  PDT,    5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
- Review, Var, NA
other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,
5470- AF,    Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin
- Review, Var, NA
TrxR↓, other↝, IL6↑, IL8↑, NK cell⇅, COX2↓, NOS2↓, NRF2↑, Prx↑, Half-Life↑, Dose↝, ROS↑, NF-kB↓,
4549- AgNPs,    Silver nanoparticles: Synthesis, medical applications and biosafety
- Review, Var, NA - Review, Diabetic, NA
ROS↑, eff↑, other↝, DNAdam↑, EPR↑, eff↑, eff↑, TumMeta↓, angioG↓, *Bacteria↓, *eff↑, *AntiViral↑, *AntiFungal↑, eff↑, eff↑, TumCP↓, tumCV↓, P53↝, HIF-1↓, TumCCA↑, lipid-P↑, ATP↓, Cyt‑c↑, MMPs↓, PI3K↓, Akt↓, *Wound Healing↑, *Inflam↓, *Bone Healing↑, *glucose↓, *AntiDiabetic↑, *BBB↑,
3443- ALA,    Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *IronCh↑, *cognitive↑, *cardioP↓, AntiCan↑, *neuroP↑, *Inflam↓, *BioAv↓, *AntiAge↑, *Half-Life↓, *BioAv↝, other↝, EGFR↓, Akt↓, ROS↓, TumCCA↑, p27/CDKN1B↑, PDH↑, Glycolysis↓, ROS↑, *eff↑, *memory↑, *motorD↑, *GutMicro↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
4758- antiOx,  Chemo,    Therapeutic controversies over use of antioxidant supplements during cancer treatment: a scoping review
- Review, Var, NA
ChemoSen↓, other↝, other↝,
4746- antiOx,  Chemo,  VitA,RetA,  VitC,  Se  Using Supplements During Chemo: Yes or No?
- Review, Var, NA
eff↓, ChemoSen↓, RadioS↓, other↝,
5453- ATV,    Epidemiologic Analysis Along the Mevalonate Pathway Reveals Improved Cancer Survival in Patients Who Receive Statins Alone and in Combination With Bisphosphonates
- Trial, Var, NA
OS↑, eff↑, other↝,
5512- bemA,    Recent advance of ATP citrate lyase inhibitors for the treatment of cancer and related diseases
- Review, Var, NA
ACLY↓, other↝, CSCs↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
4620- Bor,  BTZ,    Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
- Review, Var, NA - Review, Arthritis, NA - Review, Pca, NA
Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,
4619- Bor,    Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article
- Review, Var, NA
Dose↝, Risk↓, *antiOx↓, *Inflam↓, ChemoSen↑, AntiCan↑, *PCNA↓, *ROS↓, other↝,
5820- CBD,    Cannabidiol effects in stem cells: A systematic review
- Review, Var, NA
*other↑, CSCs↓, SOX2↓, other↝,
6000- Chit,    Chitosan in Modern Pharmacotherapy: From Drug Encapsulation to Targeted Delivery Systems
- Review, Var, NA
DDS↑, toxicity↓, TJ↓, BioAv↑, *Bacteria↓, *Inflam↓, *antiOx↓, Wound Healing↑, other↝, eff↑, eff↑,
5987- Chit,    Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine
- Review, Var, NA
other↝, other↝, *Weight↝, *toxicity↓, *Bacteria↓, *BioAv↑, DDS↑, *Wound Healing↑, *other↝, *Imm↑, eff↑, *BioAv↝, *BioAv↑, eff↑, NK cell↑, IL2↑, IFN-γ↑, IL10↑,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
6100- Chol,    Phosphatidylcholine-Derived Lipid Mediators: The Crosstalk Between Cancer Cells and Immune Cells
- Review, Var, NA
other↑, other↝, other↝, other↝, other↝,
6099- Chol,    Choline metabolism-based molecular diagnosis of cancer: an update
- Review, Var, NA
other↝, other↝,
6095- Chol,    Choline metabolism and its implications in cancer
- Review, Var, NA
BioAv↑, other↑, other↑, other↝,
6169- Cin,    Unlocking the Power of Cinnamon: A Detailed Review of Cinnamon Therapeutic Effects in Chronic Disease Management
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, IBD, NA
*neuroP↑, *AntiDiabetic↑, *tau↓, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *MDA↓, *GSH↓, *cardioP↑, *LDL↓, *HDL↑, *other↝, *TNF-α↓, *IL6↓, *MPO↓, *TLR4↓, *GutMicro↑, *lipid-P↓, *Wound Healing↑,
6147- Citrate,    The dual role of citrate in cancer
- Review, Var, NA
Glycolysis↓, Apoptosis↑, eff↝, other↝, eff↝, ChemoSen↑,
6156- CoQ10,    Metabolic Regulation of Ferroptosis in Breast Cancer
- Review, Var, NA
other↝, Ferroptosis↑, GPx4↓,
6369- CPLE,    Carica papaya leaf extract (CPLE) versus placebo to improve chemotherapy induced thrombocytopenia (CIT): Results of a phase III triple blinded, randomized placebo controlled trial (PACT study).
- Trial, Var, NA
PC↑, other↝, CIT↓,
6171- Cu,    Copper in the tumor microenvironment and tumor metastasis
- Review, Var, NA
*angioG↑, other↑, *ROS↑, CTR1↝, other↝, COX17↝, ATOX1↝,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2↓, CD31↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6704- DFC,    Diclofenac demonstrates notable anticancer properties
- Review, Var, NA
TumMeta↓, other↝,
2170- dietMet,    Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population
- Study, Var, NA
OS↑, eff↝, other↝,
5193- dietMet,  Rad,    A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Trial, Var, NA
toxicity↝, other↝,
6344- DRE,    Dandelion: Purported Benefits, Side Effects & More
- Review, Var, NA
*other↝, *hepatoP↑, *ALAT↓, *MDA↓, *TNF-α↓, *IL6↓, *antiOx↑, *Inflam↓, *proCasp3↓, Casp3↑, tumCV↓, TNF-α↑, IL1↑,
6603- Ech,  doxoR,    The effect of Echinacea purpurea on the pharmacokinetics of docetaxel
- Trial, Var, NA
other∅, other↝, Imm↑, CYP3A4⇅, other↑,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
5493- EP,    Schottky nanodiodes array enabled triboelectric nanosecond pulse generator for ultralow-cost tumor therapy
- Review, Var, NA
other↝, other↝, Ca+2↑, TumCD↑, Imm↑, TumCG↓, other↓,
5494- EP,    An Overview of Subnanosecond Pulsed Electric Field Biological Effects: Toward Contactless Technologies for Cancer Treatment
- Review, Var, NA
other↝, ROS↑, Temp∅, CellMemb↑, Ca+2↑, Apoptosis↑, TumCD↑, MMP↓, necrosis↑, TumVol↓, Remission↑,
7098- Geld,    Geldanamycins: Potent Hsp90 Inhibitors with Significant Potential in Cancer Therapy
- Review, Var, NA
HSP90↓, *toxicity↑, *toxicity↓, *BioAv↑, eff↑, *toxicity↓, other↝,
4664- GEN,  CUR,  RES,  EGCG,  SFN  Targeting cancer stem cells by nutraceuticals for cancer therapy
- Review, Var, NA
CSCs↓, other↝, eff↑, CD44↓, p‑STAT3↓,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
2522- H2,    A Systematic Review of Molecular Hydrogen Therapy in Cancer Management
- Review, Var, NA
chemoP↑, OS↑, QoL↑, TumVol↑, ROS↑, AntiTum↑, other↝,
2517- H2,    Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
- in-vitro, Var, A549 - in-vitro, NA, HCT116 - in-vitro, NA, HeLa - in-vitro, NA, HepG2 - in-vitro, NA, HT1080 - in-vitro, NA, PC3 - in-vitro, NA, SH-SY5Y
TumCP↓, other↝, eff↝, mt-UPR↑,
2528- H2,    Local generation of hydrogen for enhanced photothermal therapy
- in-vitro, Var, NA
eff↑, ROS↓, selectivity↑, ROS↑, other↝, ROS↑,
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,
2241- MF,    Pulsed electromagnetic therapy in cancer treatment: Progress and outlook
- Review, Var, NA
other↝, p‑ERK↝, P53↝, Cyt‑c↝, OXPHOS↑, Apoptosis↑, ROS↑,
4567- MFrot,    Oncogenic pathways and the electron transport chain: a dangeROS liaison
- Review, Var, NA
ROS↑, ETC↓, other↝, Fenton↑, RNS↑,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
4357- RF,    Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies
- Review, Var, NA
other↝, Dose↝, AntiTum↑, Ca+2↝, eff↝,
2551- SDT,    Sonoporation: Past, Present, and Future
- Review, Var, NA
other↝, sonoP↑, Dose↝,
1690- Se,    Selenium and cancer: a story that should not be forgotten-insights from genomics
- Review, Var, NA
Dose↓, other↝,

Showing Research Papers: 1 to 50 of 57
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CIT↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   HLA-I/II↑, 1,   miR-375↑, 1,   PC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↓, 1,   CYP1A1↑, 1,   CYP2E1↑, 1,   Fenton↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 3,   GSTZ1↓, 1,   lipid-P↑, 2,   NRF2↓, 2,   NRF2↑, 2,   OXPHOS↓, 1,   OXPHOS↑, 2,   Prx↑, 1,   RNS↑, 1,   ROS↓, 2,   ROS↑, 17,   mt-ROS↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 4,   COX17↝, 1,   ETC↓, 1,   MMP↓, 3,   MPT↑, 1,   mtDam↑, 3,   OCR↓, 1,   OCR↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 1,   CYP3A4↓, 1,   CYP3A4⇅, 1,   Glycolysis↓, 6,   HK2↓, 2,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   lipoGen↓, 1,   NADPH↓, 1,   PDH↑, 1,   PDK1↓, 1,   PKM2↓, 1,   PPP↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   Apoptosis↑, 13,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp↑, 2,   Casp3↑, 5,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 3,   Cyt‑c↝, 1,   DR4↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   MDM2↓, 1,   MOMP↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 6,   other↝, 56,   other∅, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP90↓, 1,   mt-UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 1,   P53↝, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 4,   EMT↓, 3,   ERK↓, 3,   p‑ERK↝, 1,   mTOR↓, 2,   PI3K↓, 4,   RAS↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   TumCG↓, 2,   TumCG↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   ATOX1↝, 1,   Ca+2↑, 3,   Ca+2↝, 1,   CD31↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP2↓, 3,   MMP9↓, 2,   MMPs↓, 3,   N-cadherin↓, 1,   Rho↝, 1,   TGF-β↓, 1,   TIMP1↑, 2,   TJ↓, 1,   TumCA↓, 1,   TumCI↓, 5,   TumCMig↓, 3,   TumCP↓, 8,   TumCP↑, 1,   TumMeta↓, 8,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 3,   EPR↑, 3,   HIF-1↓, 2,   Hif1a↓, 3,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CTR1↝, 1,   P-gp↓, 1,   sonoP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 3,   COX2↑, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IL1↑, 1,   IL10↑, 2,   IL2↑, 1,   IL6↓, 1,   IL6↑, 1,   IL8↓, 1,   IL8↑, 1,   Imm↑, 4,   Inflam↓, 1,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 8,   NK cell↑, 2,   NK cell⇅, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,   Temp∅, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 6,   BioEnh↑, 1,   ChemoSen↓, 2,   ChemoSen↑, 10,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   DDS↑, 3,   Dose↓, 2,   Dose↝, 9,   eff↓, 6,   eff↑, 26,   eff↝, 6,   Half-Life↓, 2,   Half-Life↑, 2,   MDR1↓, 1,   P450↓, 1,   RadioS↓, 1,   RadioS↑, 3,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 3,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   IL6↑, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 3,   chemoP↑, 3,   chemoPv↑, 2,   fatigue↓, 1,   OS↑, 3,   QoL↑, 2,   Remission↑, 1,   Risk↓, 5,   toxicity↓, 4,   toxicity↑, 1,   toxicity↝, 3,   TumVol↓, 2,   TumVol↑, 1,   TumW↓, 1,   Wound Healing↑, 1,  
Total Targets: 215

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   Catalase↑, 2,   GPx↑, 1,   GPx1↑, 1,   GSH↓, 1,   GSH↑, 3,   GSTs↑, 1,   HDL↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 3,   MPO↓, 1,   NRF2↑, 1,   ROS?, 1,   ROS↓, 5,   ROS↑, 1,   SOD↑, 1,   SOD1↑, 2,   SOD2↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   LDL↓, 3,  

Cell Death(tgid=5) ⓘ

proCasp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↑, 1,   other↝, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL23↓, 1,   IL6↓, 3,   Imm↑, 3,   Inflam↓, 9,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   TLR4↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 5,   BioAv↝, 3,   Dose↑, 1,   Dose↝, 2,   eff↑, 2,   Half-Life↓, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   GutMicro↑, 3,   IL6↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 4,   Bone Healing↑, 1,   cardioP↓, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 3,   memory↑, 2,   motorD↑, 1,   neuroP↑, 4,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 1,   Weight↝, 1,   Wound Healing↑, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 2,   Bacteria↓, 4,  
Total Targets: 86

Scientific Paper Hit Count for: other, other
3 Selenium
3 chitosan
3 Choline
3 Hydrogen Gas
3 Selenite (Sodium)
2 Anti-oxidants
2 Chemotherapy
2 Boron
2 Curcumin
2 diet Methionine-Restricted Diet
2 Electrical Pulses
2 Selenium NanoParticles
1 2-DeoxyGlucose
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Auranofin
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Vitamin A, Retinoic Acid
1 Vitamin C (Ascorbic Acid)
1 Atorvastatin
1 bempedoic acid
1 Brucea javanica
1 brusatol
1 borneol
1 Bortezomib
1 Cannabidiol
1 Cinnamon
1 Citric Acid
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Diclofenac
1 Radiotherapy/Radiation
1 Dandelion Root
1 Echinacea
1 doxorubicin
1 Emodin
1 Geldanamycin
1 Genistein (soy isoflavone)
1 Resveratrol
1 EGCG (Epigallocatechin Gallate)
1 Sulforaphane (mainly Broccoli)
1 Gossypol/AT-101
1 Hibiscus sabdariffa
1 Magnetic Fields
1 Magnetic Field Rotating
1 Nimbolide
1 Phenethyl isothiocyanate
1 Radio Frequency
1 SonoDynamic Therapy UltraSound
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:26  Cells:%  prod#:%  Target#:767  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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