CTSB Cancer Research Results

CTSB, Cathepsin B: Click to Expand ⟱
Source:
Type:
CTSB — Cathepsin B

Primary role: Lysosomal cysteine protease; executor of late-stage autophagic flux and mediator of lysosome-dependent cell death.

Cancer relevance:
CTSB is frequently overexpressed and mislocalized in cancer. In intact lysosomes, it enables productive autophagic flux by degrading autophagic cargo. Upon lysosomal membrane permeabilization (LMP), CTSB is released into the cytosol where it activates apoptotic signaling (including caspase-dependent and independent pathways). Extracellular CTSB promotes ECM degradation, invasion, and metastasis.

Net effect in established cancer:
Context-dependent, but predominantly pro-tumor via invasion and survival; pro-death when lysosomal integrity is lost.
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
6456- TUR,    Ar-turmerone inhibits the proliferation and mobility of glioma by downregulating cathepsin B
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCP↓, TumCCA↑, CTSB↓, cl‑p27↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

cl‑p27↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CTSB↓, 1,  

Migration ⓘ

TumCP↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTSB, Cathepsin B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:1429  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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