mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- NA, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2↓, CA↓, ALDH↓, P-gp↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
6239- CUSP9,    The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy
- in-vitro, GBM, NA
eff↑, tumCV↓, CSCs↓, Akt↓, mTOR↓, STAT↓,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
2127- TQ,    Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
- Review, GBM, NA
chemoP↑, ChemoSen↑, BioAv↑, PTEN↑, PI3K↓, Akt↓, TumCCA↓, NF-kB↓, p‑Akt↓, p65↓, XIAP↓, Bcl-2↓, COX2↓, VEGF↓, mTOR↓, RAS↓, Raf↓, MEK↓, ERK↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, Casp↑, cl‑PARP↑, ROS⇅, ROS↑, MMP↓, eff↑, Telomerase↓, DNAdam↑, Apoptosis↑, STAT3↓, RadioS↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Copper↓, 1,   HO-1↑, 1,   ROS↑, 3,   ROS⇅, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MEK↓, 1,   MMP↓, 2,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Proteasome↓, 1,   survivin↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   p70S6↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSF1↓, 1,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycD3↓, 1,   TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   CSCs↓, 1,   ERK↓, 2,   HH↓, 1,   mTOR↓, 5,   p85S6K↓, 1,   PI3K↓, 3,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   CA↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2↓, 2,   NF-kB↓, 2,   p65↓, 1,   TLR2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 1,   eff↓, 1,   eff↑, 2,   RadioS↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 67

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
2 CUSP9
1 Ashwagandha(Withaferin A)
1 Ginger/6-Shogaol/Gingerol
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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