P-gp Cancer Research Results

P-gp, permeability-glycoprotein: Click to Expand ⟱
Source:
Type:
P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).
GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2↓, ALDH↓, TumAuto↑, P-gp↓, eff↑,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- NA, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2↓, CA↓, ALDH↓, P-gp↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Copper↓, 1,   ROS↓, 1,   ROS↑, 1,   TrxR↓, 2,  

Cell Death ⓘ

Akt↓, 1,   Proteasome↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

CycD3↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 3,   HH↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,  

Migration ⓘ

5LO↓, 1,   CA↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   NF-kB↓, 1,   TLR2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: P-gp, permeability-glycoprotein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:232  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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