Cancer Database Query Results

GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
1336- 2DG,    2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
- in-vitro, GBM, SK-N-SH
ROS↑, GlucoseCon↓, other↓,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
1094- ACNs,    Anthocyanidins inhibit epithelial-mesenchymal transition through a TGF-β/Smad2 signaling pathway in glioblastoma cells: Anthocyanidins inhibit TGF-β-mediated EMT.
- in-vitro, GBM, U87MG
EMT↓,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
4403- AgNPs,    Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, GL26 - in-vitro, Cerv, HeLa - in-vitro, CRC, RKO
AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,
4399- AgNPs,  Chit,    Silver nanoparticles impregnated alginate-chitosan-blended nanocarrier induces apoptosis in human glioblastoma cells
- in-vitro, GBM, U87MG
DNAdam↑, ROS↑, MMP↓, eff↑,
4358- AgNPs,  HPT,  Rad,    Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells
- in-vitro, GBM, U251
RadioS↑, eff↑, TumCD↑,
4563- AgNPs,  Rad,    Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study
- in-vitro, BC, MCF-7 - in-vitro, Ovarian, SKOV3 - in-vitro, GBM, U87MG - in-vitro, Melanoma, A431
RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,
328- AgNPs,  Rad,    Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
- vitro+vivo, GBM, U251
Apoptosis↑, TumAuto↑,
333- AgNPs,  HPT,    Enhancement effect of cytotoxicity response of silver nanoparticles combined with thermotherapy on C6 rat glioma cells
- in-vivo, GBM, NA
OS↑,
332- AgNPs,  Rad,    Enhancement of Radiosensitization by Silver Nanoparticles Functionalized with Polyethylene Glycol and Aptamer As1411 for Glioma Irradiation Therapy
- in-vivo, GBM, NA
OS↑,
331- AgNPs,  Rad,    Silver nanoparticles: a novel radiation sensitizer for glioma?
- vitro+vivo, GBM, NA
OS↑,
330- AgNPs,  Rad,    Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
- in-vitro, GBM, U251
TumAuto↑, ROS↑,
329- AgNPs,  Rad,    Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells
- in-vitro, GBM, U251
Apoptosis↑, TumAuto↑,
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
235- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,
1157- And,    Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression
- in-vitro, GBM, GBM8401 - in-vitro, GBM, U251
TumCI↓, TumCMig↓, MMP2↓, ERK↝,
2319- Api,    Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis
- in-vitro, GBM, NA
Glycolysis↓, NF-kB↓, p65↓, Hif1a↓, GLUT1↓, GLUT3↓, PKM2↓, RadioS↑, TumVol↓, TumW↓,
307- Api,    Flavonoids inhibit angiogenic cytokine production by human glioma cells
- in-vitro, GBM, GL-15
TGF-β↓,
308- Api,    Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling
- in-vitro, GBM, U87MG - in-vitro, GBM, U373MG
cMET↓, Akt↓, Nanog↓, SOX2↓,
3345- ART/DHA,    Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- in-vitro, GBM, NA
ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,
5133- ART/DHA,    Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,
575- ART/DHA,    Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition
- in-vitro, GBM, U87MG
GPx4↓, xCT∅, ROS↑, Ferroptosis↑, ACSL4∅,
571- ART/DHA,  TMZ,    Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- vitro+vivo, GBM, A172 - vitro+vivo, GBM, U87MG
HR↓, RAD51↓, Apoptosis↑, necrosis↑, ROS↑, ChemoSen↑,
569- ART/DHA,    Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
- in-vitro, GBM, NA
TumCP↓, Apoptosis↑, TumCCA↑, Casp3↑, p‑Akt↓,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
4817- ASTX,    Low Dose Astaxanthin Treatments Trigger the Hormesis of Human Astroglioma Cells by Up-Regulating the Cyclin-Dependent Kinase and Down-Regulated the Tumor Suppressor Protein P53
- in-vitro, GBM, U251
Dose⇅, ROS∅, SOD↑, CDK1↑, P53↓, TumCP⇅, ROS↑,
5451- ATV,    In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG - in-vitro, GBM, A172
TumAuto↑, CSCs↓, HMG-CoA↓, TumCP↓, tumCV↓, TumCCA↑, TumCG↓, HMGCR↓,
2619- Ba,    Tumor cell membrane-coated continuous electrochemical sensor for GLUT1 inhibitor screening
- in-vitro, HCC, HepG2 - in-vitro, GBM, U87MG - in-vitro, BC, MGC803 - in-vitro, Lung, A549
GLUT1↓, TumCP↓,
5549- BBM,    Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells
- in-vitro, GBM, NA
eff?, tumCV↓, TumCG↓, ROS↑, P53↑, CSCs↓, CD133↓, ALDH1A1↓, Nanog↓, SOX2↓, OCT4↓, CDK1↓, CaMKII ↓, STAT3↓, Akt↓, ERK↓,
1401- BBR,    Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity
- in-vitro, GBM, U87MG
TumCP↓, Apoptosis↑, ROS↑,
1402- BBR,    Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction
- in-vitro, GBM, T98G
tumCV↓, ROS↑, Ca+2↑, ER Stress↑, eff↓, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, cl‑PARP↑,
2700- BBR,    Cell-specific pattern of berberine pleiotropic effects on different human cell lines
- in-vitro, GBM, U343 - in-vitro, GBM, MIA PaCa-2 - in-vitro, Nor, HDFa
selectivity↑, TumCCA↑, Casp3↑, TumCI↓, TumCMig↓, N-cadherin?, DNMT1↑,
2693- BBR,    Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
Casp1↓, ERK↓, IL1β↓, IL18↓, EMT↑,
5584- BetA,    Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
- in-vitro, GBM, A172 - in-vitro, GBM, U118MG - in-vitro, GBM, U251
Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2757- BetA,    Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways
- in-vitro, GBM, U251
tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,
5596- BEV,    Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
- Study, GBM, NA
QoL↑, OS∅,
5725- BF,  TMZ,    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide
- in-vitro, GBM, NA
TumCG↓, TumCP↓, CSCs↓, cl‑Casp3↑, PARP↑, Telomerase↓, eff↑,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
739- Bor,    Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HMC3
TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,
745- Bor,    Investigation of cytotoxic antiproliferative and antiapoptotic effects of nanosized boron phosphate filled sodium alginate composite on glioblastoma cancer cells
- in-vitro, GBM, U87MG - in-vitro, Nor, L929 - in-vitro, GBM, T98G
TumCD↑, *toxicity↓,
738- Bor,    Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
- in-vitro, GBM, U251 - in-vitro, GBM, A172 - in-vitro, Nor, SVGp12
TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,
729- Bor,    Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
- in-vitro, GBM, U87MG - in-vivo, Nor, HaCaT
TOS↑, TumCG↓, MDA↑, SOD↑, Catalase↑, TAC↓, GSH↓, BRAF↑, MAPK↓, PTEN↓, Raf↓, *toxicity↓,
5674- BTZ,    Bortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic, anti-tumor effects
- in-vivo, GBM, NA - in-vivo, HNSCC, NA
ER Stress↑, GRP78/BiP↑, CHOP↑, PERK↑, IRE1↑, UPR↑, HSP70/HSPA5↑, HSP90↑, eff↑,

Showing Research Papers: 1 to 50 of 155
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 155

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 5,   GPx↓, 1,   GPx4↓, 3,   GPx4↑, 1,   GSH↓, 4,   HO-1↑, 2,   lipid-P↑, 1,   MDA↑, 4,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↑, 23,   ROS∅, 1,   SOD↑, 2,   TAC↓, 1,   TOS↑, 1,   TrxR↓, 1,   xCT∅, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 5,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   ACSL4∅, 1,   ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   Histones↑, 1,   HK2↓, 1,   HMG-CoA↓, 1,   LDH↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 3,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 13,   mt-Apoptosis↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 3,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp7↑, 3,   Casp9↑, 3,   Cyt‑c↑, 3,   Ferroptosis↑, 5,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   necrosis↑, 1,   p38↑, 1,   Telomerase↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   CaMKII ↓, 1,   p70S6↓, 1,   Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 3,   HSF1↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   TumAuto↑, 6,  

DNA Damage & Repair ⓘ

ATM↑, 1,   ATR↑, 1,   DNAdam↑, 4,   DNMT1↑, 1,   HR↓, 1,   MGMT↓, 1,   P53↓, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 1,   RAD51↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK1↑, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   BRAF↑, 1,   CD133↓, 1,   cMET↓, 1,   CSCs↓, 4,   EIF4E↓, 2,   EMT↓, 2,   EMT↑, 1,   ERK↓, 2,   ERK↑, 1,   ERK↝, 1,   p‑ERK↑, 1,   HDAC↓, 1,   HMGCR↓, 1,   mTOR↓, 1,   mTORC1↓, 2,   Nanog↓, 2,   OCT4↓, 1,   p85S6K↓, 1,   p‑PI3K↓, 1,   PTEN↓, 1,   SOX2↓, 2,   STAT3↓, 2,   TOP1↓, 1,   TumCG↓, 5,  

Migration ⓘ

Ca+2↑, 1,   MMP2↓, 1,   N-cadherin?, 1,   PCBP1↓, 1,   TET1?, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 8,   TumCP⇅, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↑, 1,   EPR↑, 2,   Hif1a↓, 4,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↓, 2,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL18↓, 1,   IL1β↓, 1,   NF-kB↓, 2,   p65↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 1,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 6,   Dose⇅, 1,   eff?, 1,   eff↓, 5,   eff↑, 8,   eff↝, 2,   RadioS↑, 5,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

BRAF↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   OS↑, 3,   OS∅, 1,   QoL↑, 1,   TumVol↓, 2,   TumW↓, 2,  
Total Targets: 159

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   ROS↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   motorD↑, 1,   neuroP↑, 1,   toxicity↓, 3,  
Total Targets: 9

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
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