Cancer Database Query Results

GBM, Glioblastoma: Click to Expand ⟱
Glioblastoma is a fast-growing and aggressive brain tumor.
Scientific Papers found: Click to Expand⟱
8330- ,    SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
- in-vitro, GBM, U87MG
tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,
1336- 2DG,    2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells
- in-vitro, GBM, SK-N-SH
ROS↑, GlucoseCon↓, other↓,
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
3452- 5-ALA,    5-ALA Is a Potent Lactate Dehydrogenase Inhibitor but Not a Substrate: Implications for Cell Glycolysis and New Avenues in 5-ALA-Mediated Anticancer Action
- in-vitro, GBM, T98G - in-vitro, GBM, LN-18 - in-vitro, GBM, U87MG
Glycolysis↓, LDH↓, eff↝, ECAR↓,
1094- ACNs,    Anthocyanidins inhibit epithelial-mesenchymal transition through a TGF-β/Smad2 signaling pathway in glioblastoma cells: Anthocyanidins inhibit TGF-β-mediated EMT.
- in-vitro, GBM, U87MG
EMT↓,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
4403- AgNPs,    Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, GL26 - in-vitro, Cerv, HeLa - in-vitro, CRC, RKO
AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,
4399- AgNPs,  Chit,    Silver nanoparticles impregnated alginate-chitosan-blended nanocarrier induces apoptosis in human glioblastoma cells
- in-vitro, GBM, U87MG
DNAdam↑, ROS↑, MMP↓, eff↑,
4358- AgNPs,  HPT,  Rad,    Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells
- in-vitro, GBM, U251
RadioS↑, eff↑, TumCD↑,
4563- AgNPs,  Rad,    Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study
- in-vitro, BC, MCF7 - in-vitro, Ovarian, SKOV3 - in-vitro, GBM, U87MG - in-vitro, Melanoma, A431
RadioS↑, ROS↑, TumCCA↑, Apoptosis↑, ER Stress↑,
328- AgNPs,  Rad,    Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
- vitro+vivo, GBM, U251
Apoptosis↑, TumAuto↑,
333- AgNPs,  HPT,    Enhancement effect of cytotoxicity response of silver nanoparticles combined with thermotherapy on C6 rat glioma cells
- in-vivo, GBM, NA
OS↑,
332- AgNPs,  Rad,    Enhancement of Radiosensitization by Silver Nanoparticles Functionalized with Polyethylene Glycol and Aptamer As1411 for Glioma Irradiation Therapy
- in-vivo, GBM, NA
OS↑,
331- AgNPs,  Rad,    Silver nanoparticles: a novel radiation sensitizer for glioma?
- vitro+vivo, GBM, NA
OS↑,
330- AgNPs,  Rad,    Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs
- in-vitro, GBM, U251
TumAuto↑, ROS↑,
329- AgNPs,  Rad,    Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells
- in-vitro, GBM, U251
Apoptosis↑, TumAuto↑,
248- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,
235- AL,    Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway
- in-vitro, GBM, U87MG
Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,
2663- AL,    Therapeutic Effect of Allicin on Glioblastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
BioAv↝, TumCCA↑, P53↑, HDAC↓, CSCs↓, ROS↑, ChemoSen↑, MGMT↓,
1157- And,    Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression
- in-vitro, GBM, GBM8401 - in-vitro, GBM, U251
TumCI↓, TumCMig↓, MMP2↓, ERK↝,
6405- ANE,    Anethole inhibits human U87 Glioma cell proliferation by inducing apoptosis via the PI3K/AKT pathway
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
BAX↑, Bcl-2↓, PI3K↓, Akt↓, TumCP↓, Apoptosis↑,
307- Api,    Flavonoids inhibit angiogenic cytokine production by human glioma cells
- in-vitro, GBM, GL-15
TGF-β↓,
308- Api,    Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling
- in-vitro, GBM, U87MG - in-vitro, GBM, U373MG
cMET↓, Akt↓, Nanog↓, SOX2↓,
2319- Api,    Apigenin sensitizes radiotherapy of mouse subcutaneous glioma through attenuations of cell stemness and DNA damage repair by inhibiting NF-κB/HIF-1α-mediated glycolysis
- in-vitro, GBM, NA
Glycolysis↓, NF-kB↓, p65↓, Hif1a↓, GLUT1↓, GLUT3↓, PKM2↓, RadioS↑, TumVol↓, TumW↓,
3345- ART/DHA,    Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- in-vitro, GBM, NA
ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,
575- ART/DHA,    Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition
- in-vitro, GBM, U87MG
GPx4↓, xCT/SLC7A11∅, ROS↑, Ferroptosis↑, ACSL4∅,
571- ART/DHA,  TMZ,    Artesunate enhances the therapeutic response of glioma cells to temozolomide by inhibition of homologous recombination and senescence
- vitro+vivo, GBM, A172 - vitro+vivo, GBM, U87MG
HR↓, RAD51↓, Apoptosis↑, necrosis↑, ROS↑, ChemoSen↑,
569- ART/DHA,    Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
- in-vitro, GBM, NA
TumCP↓, Apoptosis↑, TumCCA↑, Casp3↑, p‑Akt↓,
5133- ART/DHA,    Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
AntiTum↑, tumCV↓, Apoptosis↓, MMP↓, Cyt‑c↑, Casp9↑, CHOP/DDIT3↑, GRP78/BiP↑, eIF2α↑, Casp12↑, ER Stress↑, TumAuto↑, ROS↑,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
4817- ASTX,    Low Dose Astaxanthin Treatments Trigger the Hormesis of Human Astroglioma Cells by Up-Regulating the Cyclin-Dependent Kinase and Down-Regulated the Tumor Suppressor Protein P53
- in-vitro, GBM, U251
Dose⇅, ROS∅, SOD↑, CDK1↑, P53↓, TumCP⇅, ROS↑,
5451- ATV,    In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U87MG - in-vitro, GBM, A172
TumAuto↑, CSCs↓, HMG-CoA↓, TumCP↓, tumCV↓, TumCCA↑, TumCG↓, HMGCR↓,
2619- Ba,    Tumor cell membrane-coated continuous electrochemical sensor for GLUT1 inhibitor screening
- in-vitro, HCC, HepG2 - in-vitro, GBM, U87MG - in-vitro, BC, MGC803 - in-vitro, Lung, A549
GLUT1↓, TumCP↓,
5549- BBM,    Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells
- in-vitro, GBM, NA
eff?, tumCV↓, TumCG↓, ROS↑, P53↑, CSCs↓, CD133↓, ALDH1A1↓, Nanog↓, SOX2↓, OCT4↓, CDK1↓, CaMKII ↓, STAT3↓, Akt↓, ERK↓,
1401- BBR,    Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity
- in-vitro, GBM, U87MG
TumCP↓, Apoptosis↑, ROS↑,
1402- BBR,    Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction
- in-vitro, GBM, T98G
tumCV↓, ROS↑, Ca+2↑, ER Stress↑, eff↓, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, cl‑PARP↑,
2700- BBR,    Cell-specific pattern of berberine pleiotropic effects on different human cell lines
- in-vitro, GBM, U343 - in-vitro, GBM, MIA PaCa-2 - in-vitro, Nor, HDFa
selectivity↑, TumCCA↑, Casp3↑, TumCI↓, TumCMig↓, N-cadherin?, DNMT1↑,
2693- BBR,    Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
Casp1↓, ERK↓, IL1β↓, IL18↓, EMT↑,
5584- BetA,    Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors
- in-vitro, GBM, A172 - in-vitro, GBM, U118MG - in-vitro, GBM, U251
Apoptosis↑, P53↑, Cyt‑c↑, AIF↑, Casp↑, AntiTum↑, MMP↓,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2757- BetA,    Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways
- in-vitro, GBM, U251
tumCV↓, TumCMig↓, TumCI↓, Apoptosis↑, p‑PI3K↓, p‑Akt↓, Ferroptosis↑, HO-1↑, NRF2↑,
5596- BEV,    Bevacizumab may improve quality of life, but not overall survival in glioblastoma: an epidemiological study
- Study, GBM, NA
QoL↑, OS∅,
5725- BF,  TMZ,    Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide
- in-vitro, GBM, NA
TumCG↓, TumCP↓, CSCs↓, cl‑Casp3↑, PARP↑, Telomerase↓, eff↑,
5651- BNL,  Cisplatin,    Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG
ChemoSen↑, tumCV↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, ATR↑, ATM↑, P53↑, Histones↑, eff↓, Casp3↑, Casp7↑, Casp9↑,
5652- BNL,    Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
- vitro+vivo, GBM, NA
Hif1a↓, Apoptosis↑, mTORC1↓, EIF4E↓, Bcl-2↓, BAX↑, Casp3↑, ChemoSen↑, ROS↑,
5658- BNL,    Natural borneol is a novel chemosensitizer that enhances temozolomide-induced anticancer efficiency against human glioma by triggering mitochondrial dysfunction and reactive oxide species-mediated oxidative damage
- vitro+vivo, GBM, U251
ChemoSen↑, mt-Apoptosis↑, Casp↑, DNAdam↑, ROS↑, angioG↓, BBB↑, EPR↑, TumVol↓, TumW↓, BioEnh↑,
5662- BNL,  Rad,    Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma
- vitro+vivo, GBM, NA
RadioS↑, Beclin-1/ATG6↑, Hif1a↓, mTORC1↓, EIF4E↓, TumAuto↑,
739- Bor,    Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HMC3
TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1/ATG6↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,
745- Bor,    Investigation of cytotoxic antiproliferative and antiapoptotic effects of nanosized boron phosphate filled sodium alginate composite on glioblastoma cancer cells
- in-vitro, GBM, U87MG - in-vitro, Nor, L929 - in-vitro, GBM, T98G
TumCD↑, *toxicity↓,
738- Bor,    Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
- in-vitro, GBM, U251 - in-vitro, GBM, A172 - in-vitro, Nor, SVGp12
TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,

Showing Research Papers: 1 to 50 of 199
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 199

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDOB↑, 1,   AURKB↓, 1,   compII↓, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   ENO3↑, 1,   H3K9↓, 2,   HK3↑, 1,   HSP60/HSPD1↓, 1,   MYCN↑, 1,   NEAT1↓, 1,   OLIG2↓, 1,   PGK2↑, 1,   PGM3↑, 1,   PHKG1↑, 1,   PKLR↑, 1,   SCP2↓, 1,   SUV39H↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↓, 1,   Catalase↑, 1,   Ceru↓, 1,   compI↓, 2,   Copper↓, 1,   cystine↓, 1,   Fenton↑, 1,   Ferroptosis↑, 9,   GPx↓, 1,   GPx4↓, 6,   GPx4↑, 2,   GSH↓, 19,   GSH↑, 1,   GSH/GSSG↓, 2,   GSTP1/GSTπ↓, 1,   H2O2↑, 7,   mt-H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 4,   HO-1⇅, 1,   Iron↑, 2,   i-Iron↑, 1,   lipid-P↑, 6,   MDA↑, 4,   mt-NADH↓, 1,   NRF2↓, 4,   NRF2↑, 2,   OXPHOS↓, 2,   OXPHOS↑, 2,   p66Shc↓, 1,   Prx↓, 1,   Prx4↓, 1,   ROS↓, 4,   ROS↑, 77,   ROS⇅, 2,   ROS∅, 1,   mt-ROS↑, 6,   RPM↑, 1,   SIRT3↓, 1,   SOD↓, 2,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 1,   TAC↓, 1,   Thiols↓, 1,   TOS↑, 1,   Trx↑, 1,   Trx1↓, 3,   TrxR↓, 5,   TrxR1↓, 1,   xCT/SLC7A11↓, 4,   xCT/SLC7A11∅, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 8,   ETC↓, 6,   MEK↓, 3,   mitResp↓, 1,   MMP?, 1,   MMP↓, 25,   MMP↑, 1,   MPT↑, 4,   mtDam↑, 4,   OCR↓, 5,   OCR↑, 2,   PGC-1α↑, 1,   Raf↓, 2,   SDH↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   ACSL4∅, 1,   AKT1↓, 1,   ALAT∅, 1,   AMPK↑, 1,   ECAR↓, 3,   FBI-1↓, 1,   FBP1↑, 1,   FGF21↓, 2,   G6PD↓, 1,   GlucoseCon↓, 4,   GlucoseCon↑, 1,   Glycolysis↓, 12,   Glycolysis↑, 2,   Histones↑, 1,   HK2↓, 5,   HMG-CoA↓, 1,   lactateProd↓, 5,   lactateProd↑, 2,   LDH↓, 2,   LDHA↓, 1,   MCT4↓, 1,   NAD↓, 1,   NADPH↓, 1,   PCK1↑, 1,   PDH↓, 1,   PDKs↓, 2,   PFK1↓, 1,   PFKP↓, 1,   PGM1↑, 1,   PKM2↓, 5,   Pyruv↓, 1,   p‑S6↓, 1,   p‑S6K↓, 1,   SIRT1↓, 1,   TCA?, 1,   Warburg↓, 4,   Warburg↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 13,   p‑Akt↓, 7,   Apoptosis↓, 2,   Apoptosis↑, 52,   mt-Apoptosis↑, 1,   Bak↑, 2,   BAX↑, 12,   Bax:Bcl2↑, 3,   Bcl-2↓, 17,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↓, 1,   Casp↑, 6,   Casp1↓, 1,   Casp12↑, 3,   pro‑Casp12↓, 1,   Casp2↑, 1,   Casp3↑, 19,   Casp3↝, 1,   cl‑Casp3↑, 5,   Casp7↑, 4,   cl‑Casp8↑, 1,   Casp9↑, 7,   cl‑Casp9↑, 2,   Cyt‑c↑, 15,   Cyt‑c↝, 1,   DR5↑, 2,   Ferroptosis↑, 9,   GADD34↑, 1,   HGF/c-Met↓, 1,   JNK↑, 4,   p‑JNK↑, 1,   lysoMP↓, 2,   lysoMP↑, 1,   MAPK↓, 3,   MAPK↑, 3,   p‑MAPK↑, 2,   Mcl-1↓, 1,   MOMP↓, 2,   MOMP↑, 1,   necrosis↑, 4,   cl‑p27/CDKN1B↓, 1,   p38↑, 3,   p‑p38↑, 1,   Proteasome↓, 1,   PUMA↑, 1,   Pyro↑, 1,   RIP1↑, 2,   survivin↓, 1,   Telomerase↓, 2,   TRAIL↓, 1,   TumCD↑, 12,   TumCD∅, 2,   YAP/TEAD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   CaMKII ↓, 1,   p70S6↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 2,   TRPV2↑, 2,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   miR-129-5p↑, 1,   other↓, 4,   other↝, 6,   other∅, 1,   tumCV↓, 21,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   eIF2α↑, 2,   ER Stress↑, 11,   GRP78/BiP↑, 5,   HSF1↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 3,   HSP90↑, 1,   IRE1↑, 1,   PERK↑, 2,   UPR↑, 5,  

Autophagy & Lysosomes(tgid=9) ⓘ

autoF↓, 1,   Beclin-1/ATG6↑, 2,   BNIP3↝, 1,   LC3B-II↑, 1,   LC3II↑, 2,   lysosome↝, 1,   MitoP↑, 3,   p62↓, 1,   TumAuto↓, 1,   TumAuto↑, 13,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 2,   ATR↑, 1,   DNAdam↑, 17,   DNMT1↑, 1,   HR↓, 1,   MGMT↓, 2,   P53↓, 1,   P53↑, 9,   P53↝, 1,   PARP↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 7,   PCNA↓, 1,   RAD51↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   Cyc↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   CycD3↓, 1,   P21↑, 3,   TumCCA↓, 2,   TumCCA↑, 20,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   BRAF↑, 1,   CD133↓, 3,   cMET↓, 1,   CSCs↓, 8,   CTSB↓, 1,   Diff↑, 1,   EIF4E↓, 2,   EMT↓, 3,   EMT↑, 1,   ERK↓, 6,   ERK↑, 1,   ERK↝, 1,   p‑ERK↓, 1,   p‑ERK↑, 1,   FOXO1↓, 1,   Gli1↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,   HDAC↓, 4,   HH↓, 2,   HMGCR↓, 1,   HMTs↓, 2,   miR-194↑, 1,   mTOR↓, 6,   mTORC1↓, 2,   Nanog↓, 2,   Nestin↓, 1,   NOTCH1↓, 1,   OCT4↓, 2,   p85S6K↓, 1,   PI3K↓, 8,   p‑PI3K↓, 1,   PTEN↓, 2,   PTEN↑, 1,   RAS↓, 2,   SOX2↓, 3,   STAT↓, 1,   STAT3↓, 6,   p‑STAT3↓, 4,   p‑STAT5↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TRPM7↓, 3,   TumCG↓, 35,   VGCC↑, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   CA↓, 1,   Ca+2↑, 11,   Ca+2↝, 2,   cal2↑, 1,   CD31/PECAM-1↓, 1,   p‑Cofilin↑, 2,   F-actin↓, 1,   Ki-67↓, 2,   MARK4↓, 1,   MMP14↓, 1,   MMP2↓, 10,   MMP9↓, 6,   MMPs↓, 2,   N-cadherin?, 1,   NEDD9↓, 1,   PCBP1↓, 1,   Rac1↓, 1,   RIP3↑, 2,   TET1?, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TIMP2↑, 1,   TumCA↓, 1,   TumCI↓, 17,   TumCMig↓, 25,   TumCP↓, 31,   TumCP↑, 2,   TumCP⇅, 1,   TumCP∅, 1,   TumPF↓, 2,   uPA↝, 1,   α-tubulin↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   ATF4↑, 2,   EGFR↓, 2,   EPR↑, 3,   HIF-1↓, 1,   Hif1a↓, 10,   PDGFR-BB↓, 1,   VEGF↓, 8,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 6,   CellMemb↑, 2,   GLUT1↓, 2,   GLUT3↓, 1,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   IFN-γ↓, 1,   IKKα↑, 1,   IL17↑, 1,   IL18↓, 2,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 2,   IL6↑, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 2,   JAK2↓, 3,   MCP1/CCL2↓, 1,   mPGES-1↓, 1,   NF-kB↓, 9,   p65↓, 2,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 1,   RANTES?, 1,   TLR2↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,   i-pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 6,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 14,   Dose?, 1,   Dose↓, 1,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 18,   Dose∅, 2,   eff?, 1,   eff↓, 28,   eff↑, 46,   eff↝, 9,   Half-Life↝, 1,   RadioS↑, 10,   selectivity?, 1,   selectivity↑, 32,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 1,   ascitic↓, 1,   AST∅, 1,   BG↓, 1,   BRAF↑, 1,   EGFR↓, 2,   IL6↓, 2,   IL6↑, 1,   Ki-67↓, 2,   LDH↓, 2,   PD-L1↓, 1,   PD-L1↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiDiabetic↑, 1,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   neuroP↑, 2,   OS↑, 22,   OS∅, 2,   Pin1↓, 1,   QoL↑, 4,   Remission↑, 1,   toxicity↓, 5,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 9,   TumW↓, 3,   Weight∅, 1,  
Total Targets: 414

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   GSH↑, 1,   Prx4∅, 1,   ROS↓, 2,   ROS∅, 1,  

Migration(tgid=13) ⓘ

TumCP↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 5,   NF-kB↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 2,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   cytoP↑, 1,   hepatoP↑, 1,   motorD↑, 1,   neuroP↑, 3,   toxicity?, 1,   toxicity↓, 5,   toxicity∅, 7,  
Total Targets: 24

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:27  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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