SOX2 Cancer Research Results

SOX2, SOX2: Click to Expand ⟱

Source:

Type:

SOX2 is a transcription factor that plays a crucial role in the development and maintenance of various cell types, including stem cells and progenitor cells. In the context of cancer, SOX2 has been found to be overexpressed in several types of tumors, including lung, breast, and esophageal cancers.
Overexpressed in: Lung, Breast, Esophageal, Prostate, GBM, CRC.

GC, Gastric Adenocarcinoma: Click to Expand ⟱

Stomach/Gastric Cancer

Scientific Papers found: Click to Expand⟱

7285-

Gins,

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

in-vitro,

GC,

AGS

ChemoSen↑, miR-429↑, SOX2↓, PI3K↓, Akt↓, mTOR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Akt↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-429↑, 1, mTOR↓, 1, PI3K↓, 1, SOX2↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: SOX2, SOX2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells