Axin2 Cancer Research Results

Axin2, Axis Inhibition Protein 2: Click to Expand ⟱
Source:
Type:
Axin2 is a key component of the Wnt/β-catenin signaling pathway, acting primarily as a negative feedback regulator. Its expression is often used as a readout for active Wnt signaling, which in many cancers is involved in tumor initiation, progression, and cancer stem cell maintenance.

Axin2 is frequently upregulated, reflecting high Wnt/β-catenin activity.
This feedback loop is critical for tight control of cell proliferation and differentiation.
GC, Gastric Adenocarcinoma: Click to Expand ⟱
Stomach/Gastric Cancer
Scientific Papers found: Click to Expand⟱
7246- Gink,    Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma
- in-vitro, GC, DAOY - in-vitro, MB, D283
Wnt↓, tumCV↓, TumCCA↑, Axin2↓, cycD1/CCND1↓, survivin↓, β-catenin/ZEB1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Axin2↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

β-catenin/ZEB1↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Axin2, Axis Inhibition Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:28  Cells:%  prod#:%  Target#:976  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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