miR-429 Cancer Research Results

miR-429, miR-429: Click to Expand ⟱

Source:

Type:

miR-429 is a key member of the miR-200 family (miR-200a/b/c, miR-141, miR-429) and plays a central role in epithelial–mesenchymal transition (EMT), metastasis, cancer stemness, and therapy response.
Across most solid tumors, miR-429 acts as a tumor-suppressor miRNA
-miR-429 is one of the strongest EMT-suppressing miRNAs.

✔ directly represses ZEB1/ZEB2
✔ maintains E-cadherin expression
✔ blocks EMT and metastasis
✔ suppresses CSC traits
✔ improves therapy response

GC, Gastric Adenocarcinoma: Click to Expand ⟱

Stomach/Gastric Cancer

Scientific Papers found: Click to Expand⟱

7285-

Gins,

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

in-vitro,

GC,

AGS

ChemoSen↑, miR-429↑, SOX2↓, PI3K↓, Akt↓, mTOR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Akt↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-429↑, 1, mTOR↓, 1, PI3K↓, 1, SOX2↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: miR-429, miR-429

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells