TIMP2 Cancer Research Results

TIMP2, Tissue Inhibitor of Metalloproteinases-2: Click to Expand ⟱

Source:

Type:

TIMP-2 has been shown to have distinct effects on cancer progression compared to TIMP-1. Research has suggested that TIMP-2 may have anti-tumor effects in certain types of cancer, including:
• Inhibiting tumor growth: TIMP-2 has been shown to inhibit the growth of tumor cells in vitro and in vivo.
High levels of TIMP-2 have been associated with better prognosis and improved survival in some cancers.
High levels of TIMP-2 have been associated with better prognosis and improved survival in some cancers.
High TIMP-2 expression: Breast, Lung, colorectal, Prostrate.
Low TIMP-2 expression: Ovarian, Pancreatic, Gastric.

GC, Gastric Adenocarcinoma: Click to Expand ⟱

Stomach/Gastric Cancer

Scientific Papers found: Click to Expand⟱

6336-

Eug,

Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG

in-vivo,

GC,

rats

Apoptosis?, Bcl-2↓, Cyt‑c↝, Casp↑, TumCI↓, angioG↓, MMPs↓, VEGF↓, VEGFR1↓, TIMP2↑, RECK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death ⓘ

Apoptosis?, 1, Bcl-2↓, 1, Casp↑, 1, Cyt‑c↝, 1,

Migration ⓘ

MMPs↓, 1, RECK↑, 1, TIMP2↑, 1, TumCI↓, 1, VEGFR1↓, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, VEGF↓, 1,
Total Targets: 11

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TIMP2, Tissue Inhibitor of Metalloproteinases-2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells