EZH2 Cancer Research Results

EZH2, enhancer of zeste homolog 2 (Drosophila): Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
EZH2 (Enhancer of Zeste Homolog 2) is a gene that encodes a protein which is a key component of the Polycomb Repressive Complex 2 (PRC2). This complex is involved in the regulation of gene expression through histone methylation, specifically the trimethylation of histone H3 at lysine 27 (H3K27me3), which leads to transcriptional repression of target genes.
EZH2 is often overexpressed in various types of cancers, including breast, prostate, and lymphoma. This overexpression can lead to the silencing of tumor suppressor genes, contributing to uncontrolled cell proliferation and survival.
EZH2 is biology-first; its biomarker value is a readout of epigenetic state.


Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
3233- EGCG,    Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways
- in-vitro, Cerv, HeLa
DNMTs↓, DNMT1↓, DNMT3A↓, HDAC2↓, HDAC3↓, HDAC4↓, EZH2↓, PI3K↓, Wnt↓, MAPK↓, hTERT/TERT↓, MMP2↓, MMP7↓, IL6↓, MDM2↓, MMP-10↓, TP53↑, PTEN↑,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↓, 1,  

Core Metabolism/Glycolysis ⓘ

RARβ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

hTERT/TERT↓, 2,   MAPK↓, 1,   MDM2↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 4,   ac‑H3↓, 1,   ac‑H4↓, 1,   HATs↓, 1,   HATs↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 2,   DNMT3A↓, 3,   DNMTs↓, 4,   G9a↓, 1,   TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 3,   HDAC1↓, 2,   HDAC11↓, 1,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 1,   HMTs↓, 1,   HMTs↑, 1,   PI3K↓, 1,   PTEN↑, 2,   Wnt↓, 1,  

Migration ⓘ

CDH1↑, 1,   E-cadherin↑, 1,   MMP-10↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 1,   TIMP3↑, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL18↓, 1,   IL2↓, 1,   IL6↓, 1,   IL8↓, 1,   SOCS1↑, 1,  

Drug Metabolism & Resistance ⓘ

TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 4,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 1,   TP53↑, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EZH2, enhancer of zeste homolog 2 (Drosophila)
1 alpha Linolenic acid
1 EGCG (Epigallocatechin Gallate)
1 Luteolin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:108  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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