UHRF1 Cancer Research Results

UHRF1, Ubiquitin-like with PHD and RING Finger domains 1: Click to Expand ⟱
Source:
Type:
UHRF1 (Ubiquitin-like with PHD and RING Finger domains 1) is an epigenetic regulator known to be overexpressed in several cancer types. Its altered expression is often associated with poor prognosis.

-UHRF1 is critical for the maintenance of DNA methylation during replication by recruiting DNA methyltransferase 1 (DNMT1) to hemimethylated DNA.
-Evidence suggests that UHRF1 can negatively regulate p53, a key tumor suppressor protein.
-Several studies have linked high UHRF1 expression with the activation of the PI3K/AKT pathway.
Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
2104- TQ,    The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, UHRF1↓, DNMT1↓, HDAC1↓, eff↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   UHRF1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC1↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: UHRF1, Ubiquitin-like with PHD and RING Finger domains 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:1250  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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