TOP2 Cancer Research Results

TOP2, Topoisomerase II: Click to Expand ⟱
Source:
Type:
Topoisomerase II (Top2) is a critical nuclear enzyme involved in managing the topology of DNA during essential cellular processes like replication, transcription, recombination, and chromosomal segregation.

- Rapidly dividing cells, including many cancer cells, often show higher Top2 expression.
- In several cancers, such as breast, lung, and hematological malignancies, increased Top2 expression has been correlated with more aggressive tumor subtypes and poorer clinical outcomes.
- The level of Top2 expression can sometimes be used as a prognostic marker, informing predictions about disease progression and potentially patient survival.
Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
2997- GEN,    Genistein Inhibition of Topoisomerase IIα Expression Participated by Sp1 and Sp3 in HeLa Cell
- in-vitro, Cerv, HeLa
TOP2↓, Sp1/3/4↓, Apoptosis↑, TumCCA↑,
3355- QC,    Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks
- in-vitro, Cerv, HeLa
DNAdam↑, ROS↑, *antiOx↑, TOP2↓, γH2AX↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TOP2↓, 2,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: TOP2, Topoisomerase II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:1321  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page