HDAC6 Cancer Research Results

HDAC6, HDAC6: Click to Expand ⟱
Source:
Type:
Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that plays a significant role in regulating various cellular processes, and its dysregulation has been implicated in cancer pathogenesis and progression.
-HDAC6 primarily deacetylates non-histone proteins, including α-tubulin and heat shock protein 90 (Hsp90).
-Many studies have reported overexpression or hyperactivation of HDAC6 in different cancer types.
Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

EZH2↓, 1,  

DNA Damage & Repair ⓘ

DNMT3A↓, 1,   DNMTs↓, 1,   G9a↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC1↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC6↓, 1,   HMTs↓, 1,   PTEN↑, 1,  

Migration ⓘ

TIMP3↑, 1,  

Immune & Inflammatory Signaling ⓘ

SOCS1↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC6, HDAC6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:1335  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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