ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
6695- DFC,    Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK
- in-vitro, Cerv, HeLa
other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,
6971- Form,    In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa
- vitro+vivo, Cerv, HeLa
p‑Akt↓, Apoptosis↑, TumCG↓, Dose↝, PI3K↓, eff↑, ATP↓, OCR↓, TumCCA↑, IGF-1↓, angioG↓, TumCI↓,
7282- Gins,    Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
- in-vitro, Cerv, NA
compI↓, compIII↓, ETC↓, ROS↑, Apoptosis↑, tumCV↓, selectivity↑, MMP↓, ATP↓, OXPHOS↓, ECAR↓, Glycolysis↓,
1403- SDT,  BBR,    From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Lung, LLC1
eff↑, tumCV↓, ATP↓, ROS↑, Casp3↑, Casp7↑, mtDam↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   lipid-P↑, 1,   i-MDA↑, 1,   OXPHOS↓, 1,   ROS↑, 2,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 4,   compIII↓, 1,   ETC↓, 1,   MMP↓, 1,   mtDam↑, 2,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ECAR↓, 1,   Glycolysis↓, 2,   lactateProd↓, 1,   LDHA↓, 1,   p‑S6K↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 3,   Casp3↑, 1,   Casp7↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hypoxia↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,   eff↑, 2,   selectivity↑, 2,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
1 Diclofenac
1 Formononetin
1 Ginseng
1 SonoDynamic Therapy UltraSound
1 Berberine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:21  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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