Beclin-1 Cancer Research Results

Beclin-1, Beclin-1 (BECN1 gene): Click to Expand ⟱
Source:
Type: Protein Coding gene
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown.
A key biomarker of autophagy is Beclin-1. Beclin-1 stimulates LC3-I’s lipidation to produce LC3-II, which localizes to the autophagosome membrane to activate the development of autophagosomes.
-BECN1 = the official gene symbol (human gene name)
-Beclin-1 = the protein name encoded by the BECN1 gene
Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
2720- BetA,    Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vivo
- in-vitro, Cerv, HeLa
Keap1↝, ROS↑, Ca+2↑, Beclin-1↓, GRP78/BiP↑, LC3II↑, p62↑, ERStress↑, TumAuto↑,
7511- FA,    The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells
- in-vitro, Cerv, HeLa - in-vitro, Cerv, CaSki
MMP9↓, TumCCA↑, P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, LC3II↓, Beclin-1↓, ATG5↓, TumCP↓, TumCI↓, MMP9↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Keap1↝, 1,   ROS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ERStress↑, 1,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1↓, 2,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   MMP9↓, 2,   TumCI↓, 1,   TumCP↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Beclin-1, Beclin-1 (BECN1 gene)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:30  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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