Trx Cancer Research Results

Trx, Thioredoxin: Click to Expand ⟱

Source:

Type: protein

Trx is a small protein that acts as a reducing agent, donating electrons to reduce oxidized proteins and other molecules.
Trx is overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer.

- Cytosolic thioredoxin (TRX-1) and mitochondrial thioredoxin (TRX-2).

- Thioredoxin is a pivotal redox regulator that protects cells from oxidative stress and supports survival and proliferation.

- There is interest in combining thioredoxin inhibitors with conventional chemotherapy or radiotherapy to sensitize tumors to oxidative stress and improve treatment efficacy.

Cerv, Cervical Cancer: Click to Expand ⟱

Cervical Cancer

Scientific Papers found: Click to Expand⟱

1978-

CUR,

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

in-vitro,

Cerv,

HeLa

TrxR1↓, ROS↑, DNA-PK↑, eff↑, Trx↓, Trx1↓,

1975-

EGCG,

Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate

in-vitro,

Cerv,

HeLa

TrxR↓, Trx↓, ROS↑, Dose↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ROS↑, 2, Trx↓, 2, Trx1↓, 1, TrxR↓, 1, TrxR1↓, 1,

DNA Damage & Repair ⓘ

DNA-PK↑, 1,

Drug Metabolism & Resistance ⓘ

Dose↑, 1, eff↑, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Trx, Thioredoxin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells