DNMT3A Cancer Research Results

DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
DNA (cytosine-5-)-methyltransferase 3 alpha, commonly referred to as DNMT3A, is an enzyme that plays a crucial role in the process of DNA methylation, which is an important mechanism for regulating gene expression and maintaining genomic stability.
The expression levels of DNMT3A and the presence of mutations can serve as prognostic markers in certain cancers.
In some cancers, DNMT3A is overexpressed, leading to increased DNA methylation of tumor suppressor genes.
Biological Consequences of DNMT3A Loss
-Epigenetic drift rather than uniform hypomethylation
-Persistence of stem-like transcriptional programs
-Increased self-renewal of hematopoietic stem cells
-Impaired differentiation with preserved viability

Importantly, DNMT3A loss does not strongly increase proliferation on its own—it increases clonal persistence and evolutionary potential.


Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
3233- EGCG,    Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways
- in-vitro, Cerv, HeLa
DNMTs↓, DNMT1↓, DNMT3A↓, HDAC2↓, HDAC3↓, HDAC4↓, EZH2↓, PI3K↓, Wnt↓, MAPK↓, hTERT/TERT↓, MMP2↓, MMP7↓, IL6↓, MDM2↓, MMP-10↓, TP53↑, PTEN↑,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

RARβ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

hTERT/TERT↓, 2,   MAPK↓, 1,   MDM2↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 3,   HATs↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 2,   DNMT3A↓, 3,   DNMTs↓, 3,   G9a↓, 1,   TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 2,   HDAC1↓, 2,   HDAC11↓, 1,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC6↓, 1,   HDAC8↓, 1,   HMTs↓, 1,   HMTs↑, 1,   PI3K↓, 1,   PTEN↑, 2,   Wnt↓, 1,  

Migration ⓘ

CDH1↑, 1,   MMP-10↓, 1,   MMP2↓, 1,   MMP7↓, 1,   TIMP3↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   SOCS1↑, 1,  

Drug Metabolism & Resistance ⓘ

TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 3,   hTERT/TERT↓, 2,   IL6↓, 1,   TP53↑, 1,  
Total Targets: 37

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha
1 alpha Linolenic acid
1 EGCG (Epigallocatechin Gallate)
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:86  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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