HDAC1 Cancer Research Results

HDAC1, Histone Deacetylase 1: Click to Expand ⟱
Source:
Type:
HDAC1 is an enzyme that removes acetyl groups from histone tails, resulting in chromatin condensation and transcriptional repression.
– By modulating the acetylation status of histones, HDAC1 plays a key role in regulating gene expression involved in cell cycle progression, differentiation, apoptosis, and DNA repair.
– Aberrant expression or activity of HDAC1 has been linked to several cancers.
– Overexpression of HDAC1 can lead to the repression of tumor suppressor genes, thereby promoting oncogenic programs and contributing to tumor progression.
– HDAC1 is often associated with a more aggressive tumor phenotype and, in some contexts, a poorer clinical prognosis.
Therapeutic Targeting:
– HDAC inhibitors (HDACis) have emerged as anticancer agents; they work by inhibiting HDAC activity to restore acetylation levels on histones and nonhistone proteins.
Cerv, Cervical Cancer: Click to Expand ⟱
Cervical Cancer
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,
2104- TQ,    The Potential Role of Nigella sativa Seed Oil as Epigenetic Therapy of Cancer
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa
TumCP↓, Apoptosis↑, UHRF1↓, DNMT1↓, HDAC1↓, eff↝,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

RARβ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   hTERT/TERT↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 2,   HATs↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 2,   G9a↓, 1,   UHRF1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 2,   HDAC1↓, 3,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC6↓, 1,   HDAC8↓, 1,   HMTs↓, 1,   HMTs↑, 1,   PTEN↑, 1,  

Migration ⓘ

CDH1↑, 1,   TIMP3↑, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

SOCS1↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↝, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 2,   hTERT/TERT↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HDAC1, Histone Deacetylase 1
1 alpha Linolenic acid
1 Quercetin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:29  Cells:%  prod#:%  Target#:982  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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