γH2AX Cancer Research Results

γH2AX, gamma-H2AX: Click to Expand ⟱

Source:

Type:

γH2AX (gamma-H2AX) is a histone protein that plays a crucial role in the repair of DNA double-strand breaks (DSBs). It is a phosphorylated form of the H2AX protein, which is a component of chromatin.

γH2AX is often used as a biomarker for DNA damage and genomic instability. When DNA is damaged, the H2AX protein is phosphorylated, forming γH2AX, which recruits and activates DNA repair proteins to the site of damage.
γ-H2AX, a marker for DNA double-strand breaks.

Cancer cells often exhibit increased levels of γH2AX due to their high rate of DNA replication and repair errors.

Gamma-H2AX, on the other hand, refers to a phosphorylated form of H2AX.

lymphoma, Lymphoma: Click to Expand ⟱

Lymphoma is a cancer of the lymphatic system.

Scientific Papers found: Click to Expand⟱

6900-

FIS,

Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B lymphoma Raji cells

in-vitro,

lymphoma,

PI3K↓, Apoptosis↑, IAP2/BIRC3↓, mTOR↓, γH2AX↑, DNAdam↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1, IAP2/BIRC3↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1, γH2AX↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1, PI3K↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: γH2AX, gamma-H2AX

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells