Telomerase Cancer Research Results
Telomerase, Telomerase: Click to Expand ⟱
| Source: HalifaxProj (inhibit) |
| Type: |
Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of chromosomes, known as telomeres. Telomeres protect the chromosome ends from deterioration or fusion with neighboring chromosomes. In most somatic (non-reproductive) cells, telomerase activity is low or absent, leading to gradual shortening of telomeres with each cell division. This shortening is associated with cellular aging and eventual cell senescence or apoptosis (programmed cell death).
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Colon, Colon Cancer: Click to Expand ⟱
Colon cancer can start anywhere in the colon, (5 feet long) and absorbs water from stool. Rectal cancer starts in the rectum, which is the last 12 centimeters.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
Colon, |
Caco-2 |
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in-vitro, |
Colon, |
HCT116 |
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TumCP↓, Telomerase↓, Apoptosis↑, DNAdam↑, Casp9↑, cl‑PARP↑, β-catenin/ZEB1↓, eff↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death ⓘ
Apoptosis↑, 1, Casp9↑, 1, Telomerase↓, 1,
DNA Damage & Repair ⓘ
DNAdam↑, 1, cl‑PARP↑, 1,
Migration ⓘ
TumCP↓, 1, β-catenin/ZEB1↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1,
Total Targets: 8
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: Telomerase, Telomerase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:31 Cells:% prod#:% Target#:302 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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