cycA1/CCNA1 Cancer Research Results

cycA1/CCNA1, cyclin A1: Click to Expand ⟱
Source:
Type:
Cyclin A1 is a protein that plays a crucial role in the regulation of the cell cycle, which is the process by which cells grow and divide. It is overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer, and its overexpression has been linked to poor prognosis and reduced survival rates.
Bladder, Bladder Cancer: Click to Expand ⟱
Bladder Cancer
Scientific Papers found: Click to Expand⟱
5551- BBM,    Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-κB Axis
- vitro+vivo, Bladder, NA
tumCV↓, TumCP↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK2↓, EMT↓, TumMeta↓, p65↓, p‑p65↓, IKKα↓, NF-kB↑, ROS↑, NRF2↓, HO-1↓, SOD2↓, GPx1↓, Bax:Bcl2↑, TumVol↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
6902- FIS,    Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9
P53↑, NF-kB↓, TumCP↓, Apoptosis↑, TumCCA↑, P21↑, cycD1/CCND1↓, cycA1/CCNA1↓, CDK4↓, CDK2↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx1↓, 1,   HO-1↓, 1,   NRF2↓, 1,   ROS↑, 1,   ROS∅, 1,   SOD2↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   MMP↓, 1,   mtDam↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bak↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   p27/CDKN1B↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 3,   CDK4↓, 1,   cycA1/CCNA1↓, 3,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   P21↑, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IKKα↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   p65↓, 1,   p‑p65↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cycA1/CCNA1, cyclin A1
1 Berbamine
1 Betulinic acid
1 Fisetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:32  Cells:%  prod#:%  Target#:653  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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