IAP2/BIRC3 Cancer Research Results

IAP2/BIRC3, cIAP2, cellular Inhibitor of Apoptosis Protein 2: Click to Expand ⟱
Source:
Type:
IAP2 (cellular Inhibitor of Apoptosis Protein 2) is a member of the Inhibitor of Apoptosis (IAP) protein family.
• Like its family members, IAP2 functions to regulate cell survival primarily by inhibiting caspases and other components of the apoptotic machinery.
• IAP2 also influences signaling pathways, such as NF-κB, which affects inflammatory responses, cell proliferation, and survival.

• Overexpression or dysregulation of IAP2 has been observed in various malignancies.
– Elevated IAP2 levels can help tumor cells evade apoptosis, promoting tumor growth and survival.
– IAP2, similar to IAP1, may contribute to resistance against chemotherapies and targeted therapies by blocking cell death pathways.

BIRC3 - Baculoviral IAP Repeat Containing 3 / Cellular Inhibitor of Apoptosis Protein 2

Abbreviation: BIRC3, cIAP2

Type: Inhibitor of apoptosis protein / E3 ubiquitin ligase

Function: BIRC3/cIAP2 regulates apoptosis, inflammatory signaling, and cell survival through ubiquitination-dependent control of TNF receptor and NF-κB signaling pathways. It interacts with proteins including TRAF2 and RIPK1 and helps determine whether TNF-family signaling promotes survival, inflammation, or programmed cell death.

Cancer: ↕ Context-dependent. Increased BIRC3 can suppress apoptosis, activate NF-κB survival signaling, and promote resistance to chemotherapy and radiotherapy in several cancers. However, BIRC3 can also function as a tumor suppressor, particularly in some B-cell malignancies, where deletion or inactivating mutation is associated with increased NF-κB signaling, aggressive disease, and treatment resistance.
Bladder, Bladder Cancer: Click to Expand ⟱
Bladder Cancer
Scientific Papers found: Click to Expand⟱
1521- Ba,    Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
TumCG↓, Apoptosis↑, IAP1↓, IAP2/BIRC3↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS?, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BID↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   DR4↑, 1,   DR5↑, 1,   FasL↑, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   TRAIL↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IAP2/BIRC3, cIAP2, cellular Inhibitor of Apoptosis Protein 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:32  Cells:%  prod#:%  Target#:980  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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