Cancer Database Query Results

Stroke, Cerebral Ischemic Stroke: Click to Expand ⟱
Ischemic stroke is also called brain ischemia and cerebral ischemia. Ischemia is the medical term for "lack of blood supply."
Scientific Papers found: Click to Expand⟱
5430- AG,    Review of the pharmacological effects of astragaloside IV and its autophagic mechanism in association with inflammation
- Review, Stroke, NA
*cardioP↑, *MitoP↑, *ROS↓, *mtDam↓, *neuroP↓, TumAuto↓, *AntiDiabetic↑,
4577- AgNPs,    Characterization of Antiplatelet Properties of Silver Nanoparticles
- vitro+vivo, Stroke, NA
*AntiAg↑, *Bacteria↓, *Dose↝, *Dose↝, *Dose↝, *toxicity↝,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2↓, p‑FAK↓,
3161- Ash,    Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage
- in-vivo, Stroke, NA
*neuroP↑, *MDA↓, *ROS↓, *SOD↑, *GPx↑, *NRF2↑, *HO-1↑,
5508- Ba,    Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
4276- BA,    Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures
- in-vivo, Stroke, NA
*BDNF↑, *neuroP↑, *TrkB↑, *PI3K↑, *Akt↑, *MAPK↑, *ERK↑, *NO↓, *MDA↓, *SOD↑, *TNF-α↓, *IL1β↓, *IL6?,
2480- Ba,    Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways
- in-vivo, Stroke, NA
*12LOX↓, *ROS↓, *ERK↑, *Akt↑, *p38↓, *JNK↓, *NF-kB↓, *cardioP↑,
2482- Ba,    Modulation of Neuroinflammation in Poststroke Rehabilitation: The Role of 12/15-Lipoxygenase Inhibition and Baicalein
- Review, Stroke, NA
*12LOX↓, *neuroP↑, *eff↑,
2483- Ba,    Baicalein and 12/15-Lipoxygenase in the Ischemic Brain
- in-vivo, Stroke, NA
*12LOX↓, *antiOx↓, *neuroP↑,
2605- Ba,  BA,    Potential therapeutic effects of baicalin and baicalein
- Review, Var, NA - Review, Stroke, NA - Review, IBD, NA - Review, Arthritis, NA - Review, AD, NA - Review, Park, NA
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
2625- Ba,  LT,    Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocyte
- in-vivo, Stroke, NA
*lipid-P↓, *ACSL4∅, *NRF2∅, *GPx4∅, *Ferroptosis↓, *ROS↓, *MDA↓, *eff↑, *HO-1∅,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
5552- BBM,    Effects of berbamine against myocardial ischemia/reperfusion injury: Activation of the 5' adenosine monophosphate‐activated protein kinase/nuclear factor erythroid 2‐related factor pathway and changes in the mitochondrial state
- in-vivo, Stroke, NA
*eff↑, *ROS↓, *mtDam↓, *AMPK↑, *NRF2↑, *NADPH↑, *HO-1↑, *cardioP↑,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
2724- BetA,    Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
- in-vivo, Nor, NA - in-vivo, Stroke, NA
AntiTum↑, *Inflam↓, *ROS↓, *NOX4↓, *Apoptosis↓, neuroP↑,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1↓, MMP9↓, COX2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
2771- BetA,    Cardioprotective Effect of Betulinic Acid on Myocardial Ischemia Reperfusion Injury in Rats
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*cardioP↑, *LDH↓, eff↑,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp↓, eff↑, other↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5670- BNL,    Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol
- Review, Stroke, NA
*TNF-α↓, *NF-kB↓, IL1β↓, MDA↓, BioEnh↑, BBB↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
3878- Carno,    Safety and Efficacy Evaluation of Carnosine, An Endogenous Neuroprotective Agent for Ischemic Stroke
- in-vivo, Stroke, NA
*toxicity∅, *antiOx↑, *neuroP↑, *IronCh↑, *ROS↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2↓, NF-kB↓,
4261- Chol,  VitB12,  FA,  VitB2,    B-Vitamin and Choline Supplementation Changes the Ischemic Brain
- Study, Stroke, NA
*BDNF↑, *homoC↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
4257- CoQ10,    Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
- Trial, Stroke, NA
*MDA↓, *IL6↓, *SOD↑, *BDNF↑, *ROS↓, *Inflam↓, *neuroP↑,
3627- Cro,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, *monoA↑, *Aβ↓, *AChE↓, *cognitive↑, *neuroP↑, *lipid-P↓, *SOD↑, *ROS↓, *GPx↑, *MDA↓, *memory↑, *antiOx↑, *Inflam↓, *other↓, *ER Stress↓,
3217- EGCG,    Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke
- in-vivo, Stroke, NA
*angioG↑, *neuroG↑, *NRF2↑,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
4243- Gins,    Effects of Ginseng on Neurological Disorders
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*BDNF↑, *TrkB↑, *neuroP↑, *VEGF↑, *p‑tau↓, *memory↑,
2513- H2,    Hydrogen therapy: from mechanism to cerebral diseases
- Review, Stroke, NA
*BBB?, *antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Dose↝,
2510- H2,    Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
- in-vivo, Stroke, NA
*ROS↓, *antiOx↑,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3775- H2,    Molecular hydrogen therapy for neurological diseases: a review of current evidence
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑,
3777- H2,    Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑,
4236- H2,    Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *BDNF↑, *Casp3↓,
4241- HNK,    Effects of Honokiol on Neurological Injury and Cognitive Function in Mice with Intracerebral Hemorrhage by Regulating BDNF-TrkB-CREB Signaling Pathway
- in-vivo, Stroke, NA
*Apoptosis↓, *cognitive↑, *BDNF↑, *TrkB↑, *CREB↑,
2872- HNK,    Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis
- in-vivo, ALS, NA - NA, Stroke, NA - NA, AD, NA - NA, Park, NA
*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *eff↑, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,
4005- K+,    Potassium
- Review, Nor, NA - Review, Stroke, NA
*Risk↓, *Dose↝, *Risk↓, *BMD↑, *glucose↓,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
3530- Lyco,    Lycopene Scavenges Cellular ROS, Modulates Autophagy and Improves Survival through 7SK snRNA Interaction in Smooth Muscle Cells
- in-vitro, Stroke, NA
*ROS↓, *antiOx↑, *TNF-α↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
3263- Lyco,    Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
- in-vitro, Nor, H9c2 - in-vitro, Stroke, NA
*Apoptosis↓, *MMP↑, *Cyt‑c↓, *APAF1↓, *cl‑Casp9↓, *cl‑Casp3↓, *Bcl-2↑, *BAX↓, cardioP↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2↓, *RAGE↓,
4099- MF,    Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients
- Trial, Stroke, NA
*ROS↓,
4102- MF,    Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients
- Human, Stroke, NA
*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,
4098- MF,    Extremely low frequency electromagnetic field (ELF-EMF) reduces oxidative stress and improves functional and psychological status in ischemic stroke patients
- Trial, Stroke, NA
*antiOx↑, *cognitive↑, *Dose↝,
4097- MF,    Theta Frequency Electromagnetic Stimulation Enhances Functional Recovery After Stroke
- Trial, Stroke, NA
*motorD↑, *eff↑, *Dose↝,

Showing Research Papers: 1 to 50 of 99
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 99

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,  

Cell Death ⓘ

p‑Akt↓, 2,   Apoptosis↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp12↑, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 3,   Fas↑, 1,   hTERT/TERT↓, 1,   p38↑, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↑, 1,   TumAuto↓, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↑, 1,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   Let-7↑, 1,   NOTCH1↑, 1,   SHP1↑, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration ⓘ

Ca+2↑, 1,   E-cadherin↑, 1,   p‑FAK↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Smad1↑, 1,   TET1↑, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,   Twist↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   ATF4↑, 1,   Hif1a↓, 2,   VEGF↓, 3,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

BBB↑, 3,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 1,   IL1β↓, 3,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 2,   MCP1↓, 1,   NF-kB↓, 5,   PGE2↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 3,   eff↑, 7,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   AntiTum↑, 3,   cardioP↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 2,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 95

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 20,   Catalase↑, 6,   Ferroptosis↓, 2,   GPx↑, 5,   GPx1↑, 1,   GPx4↑, 1,   GPx4∅, 1,   GSH↑, 9,   GSTs↑, 2,   HNE↓, 1,   HO-1↑, 5,   HO-1∅, 1,   Keap1↓, 1,   lipid-P↓, 10,   MDA↓, 10,   MDA↑, 1,   MPO↓, 2,   NOX4↓, 3,   NRF2↑, 11,   NRF2∅, 1,   ROS?, 1,   ROS↓, 31,   SOD↑, 18,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   TBARS↓, 2,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 2,   mtDam↓, 3,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 5,   ACSL4∅, 1,   ALAT↓, 3,   AMPK↑, 1,   p‑AMPK↑, 1,   CREB↑, 2,   CRM↑, 1,   CYP3A4↓, 1,   glucose↓, 1,   H2S↑, 1,   homoC↓, 1,   LDH↓, 4,   LDL↓, 1,   lipidLev↓, 1,   NADPH↑, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 3,   APAF1↓, 1,   Apoptosis↓, 6,   BAX↓, 3,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   cl‑Casp3↓, 2,   Casp9↑, 1,   cl‑Casp9↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Fas↓, 1,   Ferroptosis↓, 2,   iNOS↓, 5,   JNK↓, 2,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 2,   GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

MitoP↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   ERK↑, 2,   GSK‐3β↓, 3,   GSK‐3β↑, 1,   HDAC↓, 1,   neuroG↑, 1,   PI3K↓, 2,   PI3K↑, 2,   STAT3↓, 2,  

Migration ⓘ

AntiAg↑, 2,   APP↓, 1,   Ca+2↓, 2,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   RAGE↓, 1,   VCAM-1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   EPR↑, 1,   NO↓, 7,   NO↑, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↑, 8,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 8,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL33↓, 1,   IL6?, 1,   IL6↓, 8,   IL6↑, 1,   IL8↓, 2,   Inflam↓, 18,   Inflam↑, 1,   NF-kB↓, 10,   PGE2↓, 3,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 13,  

Synaptic & Neurotransmission ⓘ

AChE↓, 3,   BDNF↑, 9,   GABA↝, 1,   monoA↑, 1,   tau↓, 2,   p‑tau↓, 2,   TrkB↑, 4,  

Protein Aggregation ⓘ

Aβ↓, 5,   BACE↓, 1,   NLRP3↓, 1,   β-Amyloid↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 4,   BioEnh↑, 1,   Dose↑, 1,   Dose↝, 10,   eff↑, 18,   Half-Life↝, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   AST↓, 3,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   creat↓, 2,   GutMicro↑, 2,   IL6?, 1,   IL6↓, 8,   IL6↑, 1,   LDH↓, 4,   RAGE↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 9,   cognitive↑, 10,   hepatoP↑, 5,   memory↑, 6,   motorD↑, 2,   neuroP↓, 1,   neuroP↑, 30,   OS↑, 2,   RenoP↑, 4,   Risk↓, 2,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 3,   Sepsis↓, 1,  
Total Targets: 174

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:36  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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