CXCL12 Cancer Research Results

CXCL12, SDF–1: Click to Expand ⟱
Source:
Type:
SDF–1, also known as CXCL12, is a chemokine with key roles in cell signaling, migration, angiogenesis, and the regulation of the tumor microenvironment.

-SDF–1 is widely recognized for its role in tumor progression and metastasis. In many cancers—including breast, colorectal, lung, liver, and pancreatic cancers—increased expression of SDF–1 or hyperactivation of its receptor-mediated signaling is associated with more aggressive disease features and poorer patient outcomes.
Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
220- MFrot,  MF,    Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation
- in-vitro, Melanoma, B16-F10
OS↑, DCells↑, T-Cell↑, Apoptosis↑, IL1↑, IFN-γ↓, IL10↑, TumCG↓, ROS↑, TumCP↓, TumCCA↑, ChrMod↑, CXCL9↓, CXCL12↓, CD4+↑, CD8+↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics ⓘ

ChrMod↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

CXCL12↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   CXCL9↓, 1,   DCells↑, 1,   IFN-γ↓, 1,   IL1↑, 1,   IL10↑, 1,   T-Cell↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CXCL12, SDF–1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:1247  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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