CD155 Cancer Research Results

CD155, CD155: Click to Expand ⟱
Source:
Type:

CD155 (PVR; poliovirus receptor; nectin-like protein 5/NECL-5) is an immunoglobulin-superfamily cell-adhesion molecule and immune-checkpoint ligand. It binds the inhibitory receptors TIGIT and CD96, as well as the activating receptor CD226/DNAM-1, on T cells and NK cells. CD155 is frequently overexpressed in cancer, where increased expression commonly promotes immune evasion, tumour-cell migration, invasion, proliferation, and poor prognosis. For cancer records, CD155/PVR ↑ is generally tumour-promoting, while CD155 blockade or reduction is usually considered beneficial; however, the specific receptor interaction should be recorded when known. Gene reference; Cancer review.



Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
6830- EMD,    Anticancer activity of emodin is associated with downregulation of CD155
- vitro+vivo, Melanoma, B16-BL6 - in-vitro, BC, E0771 - in-vitro, BC, 4T1
TumCP↓, TumCMig↓, TumCCA↑, CD155↓, Dose↓, other↝, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CD155↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CD155, CD155
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:1531  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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