PDK1 Cancer Research Results

PDK1, Pyruvate dehydrogenase kinase 1: Click to Expand ⟱

Source:

Type:

PDK1 (3-phosphoinositide-dependent protein kinase-1) (PDPK1) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell growth, survival, and metabolism. It is a key component of the PI3K/Akt signaling pathway, which is often dysregulated in cancer.
Overexpression or hyperactivation of PDK1 can lead to increased cell proliferation, survival, and resistance to apoptosis, contributing to tumorigenesis.
Inhibitors of PDK1 are being explored in preclinical and clinical studies as a means to disrupt cancer cell growth and survival.

Melanoma, Melanoma Skin Cancer: Click to Expand ⟱

Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.

Scientific Papers found: Click to Expand⟱

6679-

DCA,

GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial

Trial,

Melanoma,

PDK1↓, Half-Life↝, eff↑, NP/CIPN↑, Dose↝, Half-Life↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

PDK1↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1, eff↑, 1, Half-Life↝, 2,

Functional Outcomes(tgid=23) ⓘ

NP/CIPN↑, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PDK1, Pyruvate dehydrogenase kinase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells