PI3k/Akt/mTOR Cancer Research Results

PI3k/Akt/mTOR, Phosphoinositide 3-kinase/Protein Kinase B/ mammalian target of rapamycin: Click to Expand ⟱
Source:
Type:
The PI3K/Akt/mTOR signaling pathway is a critical regulator of cell growth, proliferation, survival, and metabolism.

In many cancers (such as breast, colorectal, lung, and endometrial cancers), the PI3K/Akt/mTOR pathway is often hyperactivated.

– This hyperactivation is frequently due to gene mutations (e.g., in PIK3CA), loss of PTEN, and amplification events that enhance the pathway’s activity.

– Increased activity is also observed via elevated levels of phosphorylated Akt and mTOR in tumors compared to normal tissues.
Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
242- Api,    Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, C8161
ERK↓, PI3k/Akt/mTOR↓, Casp3↑, PARP↑, p‑mTOR↓, p‑Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PI3k/Akt/mTOR↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Casp3↑, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   p‑mTOR↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PI3k/Akt/mTOR, Phosphoinositide 3-kinase/Protein Kinase B/ mammalian target of rapamycin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:254  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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