Bcl-2 Cancer Research Results

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱
Source: HalifaxProj (inhibit) CGL-Driver Genes
Type: Antiapoptotic Oncogene
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.
Melanoma, Melanoma Skin Cancer: Click to Expand ⟱
Melanoma is a rare form of skin cancer. It is more likely to invade nearby tissues and spread to other parts of the body than other types of skin cancer.
Scientific Papers found: Click to Expand⟱
1369- Ash,    Withaferin A inhibits cell proliferation of U266B1 and IM-9 human myeloma cells by inducing intrinsic apoptosis
- in-vitro, Melanoma, U266
tumCV↓, Apoptosis↑, BAX↑, Cyt‑c↑, Bcl-2↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, ROS↑, eff↓,
1400- BBR,    Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells
- in-vitro, Melanoma, U266
ROS↑, TumCCA↑, Apoptosis↑, miR-21↓, Bcl-2↓, NF-kB↓, Set9↑,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
7164- CHA,    Chaetocin induces apoptosis in human melanoma cells through the generation of reactive oxygen species and the intrinsic mitochondrial pathway, and exerts its anti-tumor activity in vivo
- vitro+vivo, Melanoma, A375
TumCP↓, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-2↓, TumCG↓, PCNA↓, tumCV↓, NRF2↑, SOD2↑, Catalase↑, NRF2↓, SOD2↓, Catalase↓, TrxR↓,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
7451- CYN,    Inhibitory effects of cynaropicrin on human melanoma progression by targeting MAPK, NF‐κB, and Nrf‐2 signaling pathways in vitro
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Apoptosis↑, TumCMig↓, TumCI↓, ERK↓, NF-kB↓, ROS↓, HO-1↑, NRF2↑, Bcl-2↓, NF-kB↓, other↝,
2849- FIS,    Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,
7060- GamB,    New targets for the antitumor activity of gambogic acid in hematologic malignancies
- Review, Melanoma, RPMI-8226
AntiCan↑, TumCP↓, Apoptosis↑, SRC3↓, DIDO1/DIO-1↑, KCNH2/hERG↓, ROS↑, Bcl-2↓, P53↑, cMyc↓, VEGF↓, Casp3↑, cl‑PARP1↑, eff↓,
7139- GI,    6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer
- vitro+vivo, Lung, A549 - in-vitro, Melanoma, A375 - in-vitro, GBM, U251
HSP60/HSPD1↓, Apoptosis↑, TumCCA↑, mtDam↑, ERK↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, TumCG↓, TumCP↓, TumCG↓, Bcl-2↓, survivin↓, BAX↑, MMP↓, Dose↝,
7320- Gos,    AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma
- Trial, Melanoma, NA
Bcl-2↓, Mcl-1↓, Apoptosis↑, eff↑, toxicity↝, ORR↑,
7353- HibSad,    Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy
- in-vitro, Melanoma, A375
cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1↑, LC3B-II↑, TumAuto↑,
7343- Hne,    Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer
- in-vitro, Melanoma, A431 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HaCaT - in-vitro, Nor, JB6
*Dose↝, *antiOx↑, selectivity↑, Bcl-2↓, BAD↑, BAX↑,
1314- MAG,    Magnolol induces apoptosis via activation of both mitochondrial and death receptor pathways in A375-S2 cells
- in-vitro, Melanoma, A375
TumCP↓, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓, BAX↑,
2329- RES,    Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis
- in-vitro, Melanoma, A375
P53↑, Bcl-2↓, BAX↑, Cyt‑c↑, ERK↓, PKM2↓, Apoptosis↑, γH2AX↑, Casp3↑, cl‑PARP1↑,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
4484- Se,  Chit,  PEG,    Anti-cancer potential of selenium-chitosan-polyethylene glycol-carvacrol nanocomposites in multiple myeloma U266 cells
- in-vitro, Melanoma, U266
tumCV↓, selectivity↑, ROS↑, MMP↓, Apoptosis↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
2120- TQ,    Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3
- in-vitro, Melanoma, A431
ROS↑, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp7↑, Casp3↑, STAT3↓, cycD1/CCND1↓, survivin↓, eff↓,

Showing Research Papers: 1 to 19 of 19

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DIDO1/DIO-1↑, 1,   HSP60/HSPD1↓, 1,   KCNH2/hERG↓, 1,   ORR↑, 1,   SRC3↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Catalase↑, 1,   GSH↓, 1,   GSH↑, 1,   GSR↑, 1,   GSTs↑, 1,   HO-1↑, 2,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 1,   ROS↑, 8,   SOD2↓, 1,   SOD2↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 3,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 1,   cMyc↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 13,   BAD↑, 2,   BAX↓, 1,   BAX↑, 11,   Bcl-2↓, 19,   Bcl-xL↓, 2,   BIM↑, 1,   cl‑Casp↑, 1,   cl‑Casp12↑, 1,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 2,   Cyt‑c↑, 3,   Fas↑, 1,   FasL↑, 1,   Mcl-1↓, 3,   MDM2↓, 1,   p27/CDKN1B↑, 1,   p‑p38↑, 1,   Set9↑, 1,   survivin↓, 4,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   other↝, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3B-II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 4,   p53 Wildtype↓, 1,   cl‑PARP↑, 1,   cl‑PARP1↑, 2,   PCNA↓, 1,   PCNA↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   EP4/PTGER4↑, 1,   ERK↓, 3,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   Src↓, 1,   STAT3↓, 3,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   cal2↑, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   N-cadherin↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 8,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   JAK2↓, 1,   NF-kB↓, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 3,   Dose↝, 1,   eff↓, 5,   eff↑, 1,   P450↓, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 2,   chemoPv↑, 1,   toxicity↝, 1,  
Total Targets: 111

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2
2 Resveratrol
1 Ashwagandha(Withaferin A)
1 Berberine
1 Celastrol
1 Chemotherapy
1 chaetocin
1 Cinnamon
1 Carvone
1 Cynaropicrin
1 Fisetin
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hibiscus sabdariffa
1 Helleborus niger extracts – Christmas Rose
1 Magnolol
1 Selenium
1 chitosan
1 polyethylene glycol
1 Terpinen-4-ol / Tea Tree Oil
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:39  Cells:%  prod#:%  Target#:27  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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